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Recent advances in arterial spin labeling perfusion MRI in patients with vascular cognitive impairment
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Huang, Dan, Guo, Yunlu, Guan, Xiaoyu, Pan, Lijun, Zhu, Ziyu, Chen, Zeng’ai, Dijkhuizen, Rick M, Duering, Marco, Yu, Fang, Boltze, Johannes and Li, Peiying (2023) Recent advances in arterial spin labeling perfusion MRI in patients with vascular cognitive impairment. Journal of Cerebral Blood Flow & Metabolism, 43 (2). pp. 173-184. doi:10.1177/0271678X221135353 ISSN 0271-678X.
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Official URL: http://doi.org/10.1177/0271678X221135353
Abstract
Cognitive impairment (CI) is a major health concern in aging populations. It impairs patients’ independent life and may progress to dementia. Vascular cognitive impairment (VCI) encompasses all cerebrovascular pathologies that contribute to cognitive impairment (CI). Moreover, the majority of CI subtypes involve various aspects of vascular dysfunction. Recent research highlights the critical role of reduced cerebral blood flow (CBF) in the progress of VCI, and the detection of altered CBF may help to detect or even predict the onset of VCI. Arterial spin labeling (ASL) is a non-invasive, non-ionizing perfusion MRI technique for assessing CBF qualitatively and quantitatively. Recent methodological advances enabling improved signal-to-noise ratio (SNR) and data acquisition have led to an increase in the use of ASL to assess CBF in VCI patients. Combined with other imaging modalities and biomarkers, ASL has great potential for identifying early VCI and guiding prediction and prevention strategies. This review focuses on recent advances in ASL-based perfusion MRI for identifying patients at high risk of VCI.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QM Human anatomy R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Cerebrovascular disease -- Complications, Dementia, Blood-vessels -- Magnetic resonance imaging, Nervous system -- Imaging, Cognition disorders in old age , Cognition disorders in old age -- Patients | ||||||||||||||||||||||||||||||
| Journal or Publication Title: | Journal of Cerebral Blood Flow & Metabolism | ||||||||||||||||||||||||||||||
| Publisher: | SAGE Publications | ||||||||||||||||||||||||||||||
| ISSN: | 0271-678X | ||||||||||||||||||||||||||||||
| Official Date: | February 2023 | ||||||||||||||||||||||||||||||
| Dates: |
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| Volume: | 43 | ||||||||||||||||||||||||||||||
| Number: | 2 | ||||||||||||||||||||||||||||||
| Page Range: | pp. 173-184 | ||||||||||||||||||||||||||||||
| DOI: | 10.1177/0271678X221135353 | ||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | Huang, Dan, Guo, Yunlu, Guan, Xiaoyu, Pan, Lijun, Zhu, Ziyu, Chen, Zeng’ai, Dijkhuizen, Rick M, Duering, Marco, Yu, Fang, Boltze, Johannes and Li, Peiying (2022) Recent advances in arterial spin labeling perfusion MRI in patients with vascular cognitive impairment. Journal of Cerebral Blood Flow & Metabolism . https://doi.org/10.1177/0271678X221135353 . Copyright © The Author(s) 2022, Article Reuse Guidelines (https://us.sagepub.com/en-us/nam/journals-permissions) . Reprinted by permission of SAGE Publications. | ||||||||||||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||||||||
| Date of first compliant deposit: | 3 November 2022 | ||||||||||||||||||||||||||||||
| Date of first compliant Open Access: | 3 November 2022 | ||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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