The Library
Watching DNA condensation induced by poly(amido amine) dendrimers with time-resolved cryo-TEM
Tools
Carnerup, Anna M., Ainalem, Marie-Louise, Alfredsson, Viveka and Nylander, Tommy (2009) Watching DNA condensation induced by poly(amido amine) dendrimers with time-resolved cryo-TEM. Langmuir, Vol.25 (No.21). pp. 12466-12470. doi:10.1021/la903068v ISSN 0743-7463.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1021/la903068v
Abstract
The condensation of DNA by poly(amido amine) dendrimers of generation 1, 2, and 4 has been followed by time-resolved cryogenic transmission electron microscopy (cryo-TEM). The recorded images show that significant morphological rearrangement occurs for DNA condensed with the lower generation dendrimers leading to the formation of toroidal aggregates. Higher charge density dendrimers, oil the other hand, give rise to globular aggregates, where no transient morphologies are observed. We suggest that the dendrimers in this case are kinetically trapped as soon as they bind to the DNA strand.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry T Technology > TA Engineering (General). Civil engineering (General) |
||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Langmuir | ||||
Publisher: | American Chemical Society | ||||
ISSN: | 0743-7463 | ||||
Official Date: | 3 November 2009 | ||||
Dates: |
|
||||
Volume: | Vol.25 | ||||
Number: | No.21 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 12466-12470 | ||||
DOI: | 10.1021/la903068v | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | EU, EU-STREP | ||||
Grant number: | 129671 |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |