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A validated method to prepare stable Tau Oligomers
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Hill, Emily, Moffat, Kevin G., Wall, Mark J., Zetterberg, Henrik, Blennow, Kaj and Karikari, Thomas K. (2022) A validated method to prepare stable Tau Oligomers. In: Cieplak, A. S., (ed.) Protein Aggregation. Methods in Molecular Biology, 2551 . New York, NY: Humana, pp. 203-224. ISBN 9781071625965
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Official URL: https://doi.org/10.1007/978-1-0716-2597-2_14
Abstract
There is growing evidence that tau oligomers are a major pathological species in a number of tauopathies including Alzheimer's disease. However, it is still unclear what exact mechanisms underlie tau oligomer-mediated dysfunction. Studies of tau oligomers in vitro are limited by the high propensity for aggregation and consequent changes in the aggregation state of the produced tau samples over time. In this protocol, we provide a step-by-step description of a validated method for producing stable and structurally characterized oligomers of tau that can be used in biochemical, cellular, and animal model studies to evaluate mechanisms of action of tau in tauopathies. [Abstract copyright: © 2023. Springer Science+Business Media, LLC, part of Springer Nature.]
| Item Type: | Book Item | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| SWORD Depositor: | Library Publications Router | ||||
| Series Name: | Methods in Molecular Biology | ||||
| Journal or Publication Title: | Methods in Molecular Biology | ||||
| Publisher: | Humana | ||||
| Place of Publication: | New York, NY | ||||
| ISBN: | 9781071625965 | ||||
| ISSN: | 1064-3745 | ||||
| Book Title: | Protein Aggregation | ||||
| Editor: | Cieplak, A. S. | ||||
| Official Date: | 31 October 2022 | ||||
| Dates: |
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| Volume: | 2551 | ||||
| Page Range: | pp. 203-224 | ||||
| DOI: | 10.1007/978-1-0716-2597-2_14 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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