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Genomic assembly of clinical Candida glabrata (Nakaseomyces glabrata) isolates reveals within-species structural plasticity and association with In Vitro antifungal susceptibility
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Stefanini, Irene, Stoakes, Emily, Wu, Houdini H. T., Xu-McCrae, Li, Hussain, Abid, Moat, John, Dowson, Christopher G., David, Miruna D. and Constantinidou, Chrystala (2022) Genomic assembly of clinical Candida glabrata (Nakaseomyces glabrata) isolates reveals within-species structural plasticity and association with In Vitro antifungal susceptibility. Microbiology Spectrum, 10 (6). e01827-22. doi:10.1128/spectrum.01827-22 ISSN 2165-0497.
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WRAP-genomic-assembly-clinical-Candida-glabrata-(Nakaseomyces glabrata)-isolates-reveals-within-species-structural-plasticity-association-In-Vitro-antifungal-susceptibility-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1605Kb) | Preview |
Official URL: https://doi.org/10.1128/spectrum.01827-22
Abstract
The opportunistic human pathogen Candida glabrata has become an increasingly important threat to human health, with infections globally characterized by high mortality rates and multidrug resistance. To face this threat, more efficient diagnostic and therapeutic approaches are required, underpinning research to help define the intraspecies epidemiology, genetic variability, and therefore, diagnostic and therapeutic target stability. Previous comparative genetics studies conducted on limited numbers of strains only revealed partial resolution of chromosomal settings. In this study, by combining short- and long-read genome sequencing, phenotypic characterization, and comparative genomics over a large set of strains, we detected strict relationships between large chromosomal rearrangements and phylogenetic clades, genes subjected to different selective pressures, and new sets of genes associated with resistance to antifungals. Overall, these results not only provide a fundamental contribution to our knowledge of C. glabrata evolution and epidemiology but may also lay the foundations for the future development of tailored therapeutic approaches.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QR Microbiology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||||
| Library of Congress Subject Headings (LCSH): | Candidiasis , Antifungal agents, Anti-infective agents, Genomics | ||||||||
| Journal or Publication Title: | Microbiology Spectrum | ||||||||
| Publisher: | American Society for Microbiology | ||||||||
| ISSN: | 2165-0497 | ||||||||
| Official Date: | 21 December 2022 | ||||||||
| Dates: |
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| Volume: | 10 | ||||||||
| Number: | 6 | ||||||||
| Article Number: | e01827-22 | ||||||||
| DOI: | 10.1128/spectrum.01827-22 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 4 January 2023 | ||||||||
| Date of first compliant Open Access: | 5 January 2023 | ||||||||
| RIOXX Funder/Project Grant: |
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