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Numerical framework for simulating bio-species transport in microfluidic channels with application to antibody biosensors
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Shahbazi, Fatemeh, Jabbari, Masoud, Esfahani, Mohammad Nasr and Keshmiri, Amir (2020) Numerical framework for simulating bio-species transport in microfluidic channels with application to antibody biosensors. MethodsX, 7 . 101132. doi:10.1016/j.mex.2020.101132 ISSN 2215-0161.
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Official URL: http://dx.doi.org/10.1016/j.mex.2020.101132
Abstract
Diagnosis is a fundamental stage in health care and medical treatment. Microfluidic biosensors and lab-on-a-chip devices are amongst the few practical tools for achieving this goal. A new computational code, specifically for designing microfluidic-integrated biosensors is developed, the details of which is presented in this work. This new approach is developed using control-volume based finite-element (CVFEM) method and solves bio-recognition chemical reactions and full Navier–Stokes equations. The results of the proposed platform are validated against the experimental data for a microfluidic based biosensor, where excellent agreement is achieved. The properties of the biosensor, sample, buffer fluid and even the microfluidic channel can easily be modified in this platform. This feature provides the scientific community with the ability to design a specific biosensor for requested point-of-care applications.
A new approach is developed using control-volume based finite-element (CVFEM) method for investigating flow inside a microfluidic-integrated biosensor. It is also used to study the influence of surface functionalization on binding cycle.
The proposed model solves bio-recognition chemical reactions as well as full Navier–Stokes and energy equations. Experimental-based or personalized equations of the chemical reactions and flow behaviour are adoptable to this code.
The developed model is Fortran-based and has the potential to be used in both industry and academia for biosensing technology.
Item Type: | Journal Article | ||||||||
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Subjects: | T Technology > TA Engineering (General). Civil engineering (General) T Technology > TJ Mechanical engineering and machinery |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||||||
Library of Congress Subject Headings (LCSH): | Microfluidics, Biosensors -- Mathematical models, Computational fluid dynamics, Fluid dynamics -- Mathematics, Numerical analysis | ||||||||
Journal or Publication Title: | MethodsX | ||||||||
Publisher: | Elsevier | ||||||||
ISSN: | 2215-0161 | ||||||||
Official Date: | November 2020 | ||||||||
Dates: |
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Volume: | 7 | ||||||||
Article Number: | 101132 | ||||||||
DOI: | 10.1016/j.mex.2020.101132 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 30 November 2022 | ||||||||
Date of first compliant Open Access: | 30 November 2022 |
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