Saiki, Atsuhito, Olsson, Maja, Jernas, Margareta, Gummesson, Anders, McTernan, P. G. (Philip G.), Andersson, Johanna, Jacobson, Peter, Sjoholm, Kajsa, Olsson, Bob, Yamamura, Shigeo, Walley, Andrew, Froguel, Philippe, Carlsson, Bjorn, Sjostrom, Lars, Svensson, Per-Arne and Carlsson, Lena M. S.. (2009) Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. Journal of Clinical Endocrinology & Metabolism , Vol.94 (No.10). pp. 3987-3994. ISSN 0021-972x

Full text not available from this repository.

Abstract

Context: Tenomodulin (TNMD), a putative angiogenesis inhibitor, is expressed in hypovascular connective tissues. Global gene expression scans show that the TNMD gene also is expressed in human adipose tissue and that its expression is regulated in response to weight reduction; however, more detailed information is lacking. Objective: The aim of this study was to investigate TNMD tissue distribution and TNMD gene expression in human adipose tissue in relation to obesity and metabolic disease. Design, Patients, and Interventions: TNMD gene expression, tissue distribution, and TNMD gene expression in adipose tissue from different depots, from lean and obese subjects, and during diet-induced weight reduction were analyzed by DNA microarray and real-time PCR. Main Outcome Measure: We primarily measured TNMD gene expression. Results: The TNMD gene was predominantly expressed in sc adipose tissue. TNMD gene expression was higher in sc than omental adipose tissue both in lean (P = 0.002) and obese subjects (P = 0.014). In both women and men, TNMD gene expression was significantly higher in the obese subjects compared to the lean subjects (P = 1.1 x 10(-26) and P = 0.010, respectively). In a multiple linear regression analysis, BMI was a significant independent predictor of TNMD gene expression. TNMD gene expression was down-regulated during diet-induced weight loss, with a 65% decrease after 18 wk of diet (P < 0.0001). Conclusions: We conclude that human adipose tissue TNMD gene expression is highly affected by obesity, adipose tissue location, and weight loss, indicating that TNMD may play a role in adipose tissue function. (J Clin Endocrinol Metab 94: 3987-3994, 2009)

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Journal of Clinical Endocrinology & Metabolism
Publisher:	Endocrine Society
ISSN:	0021-972x
Date:	October 2009
Volume:	Vol.94
Number:	No.10
Number of Pages:	8
Page Range:	pp. 3987-3994
Identification Number:	10.1210/jc.2009-0292
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Royal Society (Great Britain), Swedish Research Council, Swedish Foundation, Swedish Diabetes Foundation, Dr. P. Hakanssons Foundation, Ake Wiberg Foundation, Foundations of the National Board of Health and Welfare, Jeansson Foundations, Magn Bergvall Foundation, Tore Nilsson Foundation for Medical Research, Royal Physiographic Society (Nilsson-Ehle Foundation), VINNOVA-VINNMER, Swedish Knowledge Foundation, Swedish federal government, Wellcome Trust
Grant number:	K2007-55X-11285-13-3, K2008-65x-2075301-4, 529-2002-6671, GR079534
URI:	http://wrap.warwick.ac.uk/id/eprint/17161

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item