Scialdone, Antonio and Nicodemi, Mario. (2009) DNA loci cross-talk through thermodynamics. Journal of Biomedicine and Biotechnology . Article no. 516723. ISSN 1110-7243

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Abstract

The recognition and pairing of specific DNA loci, though crucial for a plenty of important cellular processes, are produced by still mysterious physical mechanisms. We propose the first quantitative model from Statistical Mechanics, able to clarify the interaction allowing such "DNA cross-talk" events. Soluble molecules, which bind some DNA recognition sequences, produce an effective attraction between distant DNA loci; if their affinity, their concentration, and the relative DNA binding sites number exceed given thresholds, DNA colocalization occurs as a result of a thermodynamic phase transition. In this paper, after a concise report on some of the most recent experimental results, we introduce our model and carry out a detailed "in silico" analysis of it, by means of Monte Carlo simulations. Our studies, while rationalize several experimental observations, result in very interesting and testable predictions. Copyright (C) 2009 A. Scialdone and M. Nicodemi.

Item Type:	Journal Article
Subjects:	T Technology > TP Chemical technology R Medicine
Divisions:	Faculty of Science > Centre for Complexity Science
Journal or Publication Title:	Journal of Biomedicine and Biotechnology
Publisher:	Hindawi Publishing Corp.
ISSN:	1110-7243
Date:	2009
Number of Pages:	8
Page Range:	Article no. 516723
Identification Number:	10.1155/2009/516723
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	INFM-CINECA
URI:	http://wrap.warwick.ac.uk/id/eprint/17162

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