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The use of Botulinum toxin in the management of Hidradenitis Suppurativa : a systematic review
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Geoghegan, Luke, Rodrigues, Raina, Harrison, Conrad J. and Rodrigues, Jeremy N. (2022) The use of Botulinum toxin in the management of Hidradenitis Suppurativa : a systematic review. Plastic and Reconstructive Surgery - Global Open, 10 (11). e4660. doi:10.1097/GOX.0000000000004660 ISSN 2169-7574.
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WRAP-use-Botulinum-toxin-management-Hidradenitis-Suppurativa-systematic-review-Rodrigues-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (753Kb) | Preview |
Official URL: https://doi.org/10.1097/GOX.0000000000004660
Abstract
Background:
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by suppurative infection, sinus tract, and abscess formation. International management guidelines are largely consensus-based. Botulinum toxin (BTX) has been widely used in the treatment of apocrine and eccrine gland disorders, such as hyperhidrosis, although the effectiveness of BTX in the treatment of HS remains unknown. The aim of this systematic review was to understand the published evidence of BTX safety and effectiveness in the management of HS.
Methods:
We conducted a PRISMA-compliant, prospectively registered (PROSPERO, CRD42021228732), systematic review. We devised bespoke search strategy and applied it to the Cochrane Central Register of Controlled Trials, Medline, Embase, and OpenGrey up until March 2022. We included all clinical studies that reported outcomes following BTX treatment in patients diagnosed with HS (both adult and pediatric).
Results:
A total of 4658 studies were identified, of which six met full inclusion criteria reporting data on 26 patients. The six identified studies included one randomized control trial, one case series, and four case studies. The one included randomized control trial demonstrated a significant reduction in the Dermatology Life Quality Index score at 3 months following treatment with BTX.
Conclusions:
The effectiveness and safety of BTX in the treatment of HS remain unknown. This systematic review identified a paucity of high-quality clinical data. Evidence of treatment effectiveness is likely to come from registry-based cohort studies using established core outcome sets in the first instance.
| Item Type: | Journal Article | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RB Pathology R Medicine > RC Internal medicine R Medicine > RL Dermatology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | |||||||||
| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Hidradenitis suppurativa , Hidradenitis suppurativa -- Treatment , Botulinum toxin, Botulinum toxin -- Therapeutic use | |||||||||
| Journal or Publication Title: | Plastic and Reconstructive Surgery - Global Open | |||||||||
| Publisher: | Lippincott Williams & Wilkins | |||||||||
| ISSN: | 2169-7574 | |||||||||
| Official Date: | 18 November 2022 | |||||||||
| Dates: |
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| Volume: | 10 | |||||||||
| Number: | 11 | |||||||||
| Article Number: | e4660 | |||||||||
| DOI: | 10.1097/GOX.0000000000004660 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 16 December 2022 | |||||||||
| Date of first compliant Open Access: | 16 December 2022 | |||||||||
| RIOXX Funder/Project Grant: |
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