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The differential binding and biological efficacy of auxin herbicides
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Prusińska, Justyna, Uzunova, Veselina, Schmitzer, Paul, Weimer, Monte, Bell, Jared and Napier, Richard (2023) The differential binding and biological efficacy of auxin herbicides. Pest Management Science, 79 (4). pp. 1305-1315. doi:10.1002/ps.7294 ISSN 1526-498X.
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Official URL: http://dx.doi.org/10.1002/ps.7294
Abstract
Background
Auxin herbicides have been used for selective weed control for 75 years and they continue to be amongst the most widely used weed control agents globally. The auxin herbicides fall into five chemical classes with 2 herbicides not classified, and in all cases it is anticipated that recognition in the plant starts with binding to the Transport Inhibitor Response 1 (TIR1) family of auxin receptors. There is evidence that some classes of auxins act selectively with certain clades of receptors, although a comprehensive structure-activity relationship has not been available.
Results
Using purified receptor proteins to measure binding efficacy we have conducted quantitative structure activity relationship (qSAR) assays using representative members of the three receptor clades in Arabidopsis, TIR1, AFB2 and AFB5. Complementary qSAR data for biological efficacy at the whole plant level using root growth inhibition and foliar phytotoxicity assays has also been analyzed for each family of auxin herbicides, including for the afb5-1 receptor mutant line.
Conclusions
Comparisons of all these assays highlight differences in receptor selectivity and some systematic differences between results for binding in vitro and activity in vivo. The results could provide insights to weed spectrum differences between the different classes of auxin herbicides, as well as to potential resistance and cross-resistance implications for this herbicide class.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QK Botany S Agriculture > SB Plant culture |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | Auxin , Plants -- Effect of auxin on, Herbicides , Arabidopsis | |||||||||
| Journal or Publication Title: | Pest Management Science | |||||||||
| Publisher: | Wiley | |||||||||
| ISSN: | 1526-498X | |||||||||
| Official Date: | April 2023 | |||||||||
| Dates: |
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| Volume: | 79 | |||||||||
| Number: | 4 | |||||||||
| Page Range: | pp. 1305-1315 | |||||||||
| DOI: | 10.1002/ps.7294 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 9 December 2022 | |||||||||
| Date of first compliant Open Access: | 16 December 2022 | |||||||||
| RIOXX Funder/Project Grant: |
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