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Maternal selection of human embryos in early gestation : insights from recurrent miscarriage
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Brosens, Jan J., Bennett, Phillip R., Abrahams, Vikki M., Ramhorst, Rosanna, Coomarasamy, Arri, Quenby, Siobhan, Lucas, Emma S. and McCoy, Rajiv C. (2022) Maternal selection of human embryos in early gestation : insights from recurrent miscarriage. Seminars in Cell & Developmental Biology, 131 . pp. 14-24. doi:10.1016/j.semcdb.2022.01.007 ISSN 1084-9521.
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WRAP-maternal-selection-human-embryos-early-gestation-insights-from-recurrent-miscarriage-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1589Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.semcdb.2022.01.007
Abstract
Compared to most mammals, human pregnancy is unusual in that it involves chromosomally diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate integration of fetal and maternal cells at the uteroplacental interface. Not surprisingly, pregnancy often falters in early gestation. Whether these losses result in clinical miscarriages depends on the origins and impacts of chromosomal errors on fetal development and the ability of the decidualizing endometrium to engage in embryo biosensing and selection. Aneuploidy originating in oocytes during meiosis drives the age-related risk of miscarriage. By contrast, the frequency of endometrial cycles with an impaired decidual response may account for the stepwise increase in miscarriage rates with each pregnancy loss independently of maternal age. Additional physiological mechanisms operate in early gestation to ensure that most failing pregnancies are lost before vascular maternal-fetal connections are established by the end of the first trimester. Here, we summarise how investigations into the mechanisms that cause miscarriage led to new insights into the processes that govern maternal selection of human embryos in early gestation.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QM Human anatomy Q Science > QP Physiology R Medicine > RB Pathology R Medicine > RG Gynecology and obstetrics |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Miscarriage, Human embryo, Human embryo -- Physiology, Aneuploidy, Endometrium , Placenta -- Physiology | ||||||||||||
| Journal or Publication Title: | Seminars in Cell & Developmental Biology | ||||||||||||
| Publisher: | Elsevier Ltd | ||||||||||||
| ISSN: | 1084-9521 | ||||||||||||
| Official Date: | November 2022 | ||||||||||||
| Dates: |
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| Volume: | 131 | ||||||||||||
| Page Range: | pp. 14-24 | ||||||||||||
| DOI: | 10.1016/j.semcdb.2022.01.007 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
| Date of first compliant deposit: | 20 December 2022 | ||||||||||||
| Date of first compliant Open Access: | 20 December 2022 | ||||||||||||
| RIOXX Funder/Project Grant: |
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