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Label-free protein quantitation using liquid crystal-enhanced optofluidic biosensor
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Wang, Ziyihui, Xu, Tianhua, Wang, Haonan, Liu, Yize, Liu, Kun, Jiang, Junfeng, Chen, Yu-Cheng, Liu, Tiegen, Peng, Gang-Ding, Yang, Minghong and Fan, Xinyu (2022) Label-free protein quantitation using liquid crystal-enhanced optofluidic biosensor. In: SPIE/COS Photonics Asia Digital Forum 2022, Online, 5-11 Dec 2022. Published in: Proceedings of SPIE ; Advanced Sensor Systems and Applications XII, 12321 doi:10.1117/12.2638371 ISSN 0277-786X.
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WRAP-label-free-protein-quantitation-using-liquid-crystal-enhanced-optofluidic-biosensor-Xu-2022.pdf - Accepted Version - Requires a PDF viewer. Download (815Kb) | Preview |
Official URL: http://dx.doi.org/10.1117/12.2638371
Abstract
Protein detection plays an important role in the medical research. Liquid crystals (LCs), as a class of sensitive materials, exhibit a promising ability in the biosensing field. Herein, we exploited an ultrasensitive biosensor for protein detection, employing the whispering-gallery-mode (WGM) from the LC-amplified optofluidic micro-resonator. The biomolecules can trigger both light-matter interactions and the orientation transitions of LC molecules. The WGM spectral wavelength shift was recorded as the sensing indicator, and a detection limit of 15 fM for bovine serum albumin (BSA) was achieved. Our LC-amplified optofluidic biosensor provides a new solution for the ultrasensitive, real-time, and stable biological detection.
Item Type: | Conference Item (Paper) | ||||||
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Subjects: | R Medicine > R Medicine (General) T Technology > TA Engineering (General). Civil engineering (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||
Library of Congress Subject Headings (LCSH): | Liquid crystals, Biosensors, Proteins, Optofluidics | ||||||
Journal or Publication Title: | Proceedings of SPIE ; Advanced Sensor Systems and Applications XII | ||||||
Publisher: | S P I E - International Society for Optical Engineering | ||||||
ISSN: | 0277-786X | ||||||
Book Title: | Advanced Sensor Systems and Applications XII | ||||||
Official Date: | 19 December 2022 | ||||||
Dates: |
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Volume: | 12321 | ||||||
DOI: | 10.1117/12.2638371 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Reuse Statement (publisher, data, author rights): | Copyright (2022) Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited. | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Date of first compliant deposit: | 4 January 2023 | ||||||
Date of first compliant Open Access: | 4 January 2023 | ||||||
Conference Paper Type: | Paper | ||||||
Title of Event: | SPIE/COS Photonics Asia Digital Forum 2022 | ||||||
Type of Event: | Conference | ||||||
Location of Event: | Online | ||||||
Date(s) of Event: | 5-11 Dec 2022 | ||||||
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