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15-Lipoxygenase-1 in colorectal cancer: a review
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Bhattacharya, S., Mathew, G., Jayne, D. G., Pelengaris, Stella and Khan, Michael (2009) 15-Lipoxygenase-1 in colorectal cancer: a review. Tumor Biology, Vol.30 (No.4). pp. 185-199. doi:10.1159/000236864
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Official URL: http://dx.doi.org/10.1159/000236864
Abstract
Objective: Enzymes involved in the oxidative metabolism of n-6 polyunsaturated fatty acids, like lipoxygenase (LOX) and cyclooxygenase (COX), are significant in the pathogenesis of colorectal cancer. Of these enzymes, 15-LOX-1 is expressed in colon. Aim of this article is to describe the role and regulation of 15-LOX-1 in colorectal cancer and highlight its importance in cancer therapeutics. Methods: For our electronic literature research in PubMed and MEDLINE, key words related to 15-LOX-1 and colorectal cancer were used to find articles for this review. Results: From the evidences, we believe that 15-LOX-1 has anti-carcinogenic effects in colorectal cancer, dependent or independent of its metabolites, and is manifested through downstream pathways involving cGMP, PPAR, p53, p21 and NAG-1, increasing apoptosis and decreasing proliferation in cancer cells. Regulation of 15-LOX-1 expression is achieved at transcription level by global histone acetylation and may also be dependent on GATA-6, IL-4 and IL-13. Positive relationship exists between 15-LOX-1 and survival in colorectal cancer. Conclusion: Evidences strongly support that therapeutic modulation of 15-LOX-1 may be a key to the treatment of colorectal cancer. However, it is still undecided whether the up-regulation of 15-LOX-1 alone can be sufficient to treat colorectal cancer and further studies are awaited. Copyright (C) 2009 S. Karger AG, Basel
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Tumor Biology | ||||
| Publisher: | Karger | ||||
| ISSN: | 1010-4283 | ||||
| Official Date: | 2009 | ||||
| Dates: |
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| Volume: | Vol.30 | ||||
| Number: | No.4 | ||||
| Number of Pages: | 15 | ||||
| Page Range: | pp. 185-199 | ||||
| DOI: | 10.1159/000236864 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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