Markovic, Danijela and Grammatopoulos, Dimitris K. (2009) Focus on the splicing of Secretin GPCRs transmembrane-domain 7. Trends in Biochemical Sciences, Vol.34 (No.9). pp. 443-452. ISSN 0968-0004

Full text not available from this repository.

Abstract

The family of G-protein coupled receptors (GPCRs) is one of the largest protein families in the mammalian genome with a fundamental role in cell biology. GPCR activity is finely tuned by various transcriptional, post-transcriptional and post-translational mechanisms. Alternative pre-mRNA splicing is now emerging as a crucial process regulating GPCR biological function. Intriguingly, this mechanism appears to extensively target the Secretin family of GPCRs, especially the exon that encodes a 14 amino acid sequence that forms the distal part of 7th transmembrane helix, and exhibits an unusually high level of sequence conservation among most Secretin GPCRs. Do the "TMD7-short" receptor variants have a role as novel regulators of GPCR signaling and, if so, what are the implications for hormonal actions and physiology?

Item Type:	Journal Item
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Trends in Biochemical Sciences
Publisher:	Elsevier Science London
ISSN:	0968-0004
Date:	September 2009
Volume:	Vol.34
Number:	No.9
Number of Pages:	10
Page Range:	pp. 443-452
Identification Number:	10.1016/j.tibs.2009.06.002
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/17236

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item