Focus on the splicing of Secretin GPCRs transmembrane-domain 7
Markovic, Danijela and Grammatopoulos, Dimitris K. (2009) Focus on the splicing of Secretin GPCRs transmembrane-domain 7. Trends in Biochemical Sciences, Vol.34 (No.9). pp. 443-452. ISSN 0968-0004Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.tibs.2009.06.002
The family of G-protein coupled receptors (GPCRs) is one of the largest protein families in the mammalian genome with a fundamental role in cell biology. GPCR activity is finely tuned by various transcriptional, post-transcriptional and post-translational mechanisms. Alternative pre-mRNA splicing is now emerging as a crucial process regulating GPCR biological function. Intriguingly, this mechanism appears to extensively target the Secretin family of GPCRs, especially the exon that encodes a 14 amino acid sequence that forms the distal part of 7th transmembrane helix, and exhibits an unusually high level of sequence conservation among most Secretin GPCRs. Do the "TMD7-short" receptor variants have a role as novel regulators of GPCR signaling and, if so, what are the implications for hormonal actions and physiology?
|Item Type:||Journal Item|
|Subjects:||Q Science > QD Chemistry|
|Divisions:||Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI)
Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Trends in Biochemical Sciences|
|Publisher:||Elsevier Science London|
|Number of Pages:||10|
|Page Range:||pp. 443-452|
|Access rights to Published version:||Restricted or Subscription Access|
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