The Library
Role for astrocytes in mGluR-dependent LTD in the neocortex and hippocampus
Tools
Tools
Tools
Lalo, Ulyana and Pankratov, Yuriy (2022) Role for astrocytes in mGluR-dependent LTD in the neocortex and hippocampus. Brain sciences, 12 (12). 1718. doi:10.3390/brainsci12121718 ISSN 2076-3425.
|
PDF
WRAP-role-astrocytes-mGluR-dependent-LTD-neocortex-hippocampus-Pankratov-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (7Mb) | Preview |
Official URL: http://dx.doi.org/10.3390/brainsci12121718
Abstract
Astroglia are an active element of brain plasticity, capable to release small molecule gliotransmitters by various mechanisms and regulate synaptic strength. While importance of glia-neuron communications for long-term potentiation has been rather widely reported, research into role for astrocytes in long-depression (LTD) is just gaining momentum. Here, we explored the role for astrocytes in the prominent form of synaptic plasticity—mGluR-dependent LTD. We found out the substantial contribution of the Group I receptors, especially mGluR1 subtype, into Ca2+-signaling in hippocampal and neocortical astrocytes, which can be activated during synaptic stimulation used for LTD induction. Our data demonstrate that mGluR receptors can activate SNARE-dependent release of ATP from astrocytes which in turn can directly activate postsynaptic P2X receptors in the hippocampal and neocortical neurons. The latter mechanism has recently been shown to cause the synaptic depression via triggering the internalisation of AMPA receptors. Using mouse model of impaired glial exocytosis (dnSNARE mice), we demonstrated that mGluR-activated release of ATP from astrocytes is essential for regulation of mGluR-dependent LTD in CA3-CA1 and layer 2/3 synapses. Our data also suggest that astrocyte-related pathway relies mainly on mGluR1 receptors and act synergistically with neuronal mechanisms dependent mainly on mGluR5.
| Item Type: | Journal Article | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology | |||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | Astrocytes, Neurosciences, Hippocampus (Brain), Depression, Mental, Central Nervous System -- Pathophysiology | |||||||||
| Journal or Publication Title: | Brain sciences | |||||||||
| Publisher: | MDPI | |||||||||
| ISSN: | 2076-3425 | |||||||||
| Official Date: | 15 December 2022 | |||||||||
| Dates: |
|
|||||||||
| Volume: | 12 | |||||||||
| Number: | 12 | |||||||||
| Article Number: | 1718 | |||||||||
| DOI: | 10.3390/brainsci12121718 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 6 January 2023 | |||||||||
| Date of first compliant Open Access: | 9 January 2023 | |||||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
