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Comparison of the effects of AgNPs on the morphological and mechanical characteristics of cancerous cells
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Zhu, Jiajing, Tian, Yanling, Cao, Liang, Hu, Jing, Yan, Jin, Wang, Zuobin and Liu, Xianping (2023) Comparison of the effects of AgNPs on the morphological and mechanical characteristics of cancerous cells. Journal of Microscopy, 289 (3). pp. 187-197. doi:10.1111/jmi.13166 ISSN 0022-2720.
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WRAP-Comparison-of-the-effects-of-AgNPs-on-the-morphological-and-mechanical-characteristics-of-cancerous-cells-Tian-2023.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2400Kb) | Preview |
Official URL: http://dx.doi.org/10.1111/jmi.13166
Abstract
Currently, silver nanoparticles (AgNPs) are the most produced nanoparticles in global market and have been widely utilized in the biomedical field. Here, we investigated the morphological and mechanical effects of AgNPs on cancerous cells of A549 cells and SMMC-7721 cells with atomic force microscope (AFM). The influence of AgNPs on the morphological properties and mechanical properties of cancerous cells were characterized utilizing the force–volume (FV) mode and force spectroscopy (FS) mode of AFM measurement. We mainly focus on the comparison of the effects of AgNPs on the two types of cancerous cells based on the fitting results of calculating the Young's moduli utilizing the Sneddon model. The results showed that the morphology changed little, but the mechanical properties of height, roughness, adhesion force and Young's moduli of two cancerous cells varied significantly with the stimulation of different concentrations of AgNPs. This research has provided insights into the classification and characterization of the effects of the various concentrations of AgNPs on the cancerous cells in vitro by utilizing AFM methodologies for disease therapy.
Item Type: | Journal Article | |||||||||||||||||||||||||||
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Subjects: | R Medicine > RS Pharmacy and materia medica T Technology > T Technology (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | |||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Nanotechnology, Nanoparticles, Silver, Cancer cells, Nanocomposites (Materials) | |||||||||||||||||||||||||||
Journal or Publication Title: | Journal of Microscopy | |||||||||||||||||||||||||||
Publisher: | Wiley-Blackwell Publishing, Inc | |||||||||||||||||||||||||||
ISSN: | 0022-2720 | |||||||||||||||||||||||||||
Official Date: | March 2023 | |||||||||||||||||||||||||||
Dates: |
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Volume: | 289 | |||||||||||||||||||||||||||
Number: | 3 | |||||||||||||||||||||||||||
Page Range: | pp. 187-197 | |||||||||||||||||||||||||||
DOI: | 10.1111/jmi.13166 | |||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
Date of first compliant deposit: | 24 January 2023 | |||||||||||||||||||||||||||
Date of first compliant Open Access: | 24 January 2023 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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