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Antimicrobial and cell-penetrating peptides : understanding penetration for the design of novel conjugate antibiotics
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Hadjicharalambous, Andreas, Bournakas, Nikolaos, Newman, Hector, Skynner, Michael J. and Beswick, Paul (2022) Antimicrobial and cell-penetrating peptides : understanding penetration for the design of novel conjugate antibiotics. Antibiotics, 11 (11). 1636. doi:10.3390/antibiotics11111636 ISSN 2079-6382.
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Official URL: http://dx.doi.org/10.3390/antibiotics11111636
Abstract
Antimicrobial peptides (AMPs) are short oligopeptides that can penetrate the bacterial inner and outer membranes. Together with cell-penetrating peptides (CPPs), they are called membrane active peptides; peptides which can translocate across biological membranes. Over the last fifty years, attempts have been made to understand the molecular features that drive the interactions of membranes with membrane active peptides. This review examines the features of a membrane these peptides exploit for translocation, as well as the physicochemical characteristics of membrane active peptides which are important for translocation. Moreover, it presents examples of how these features have been used in recent years to create conjugates consisting of a membrane active peptide, called a “vector”, attached to either a current or novel antibiotic, called a “cargo” or “payload”. In addition, the review discusses what properties may contribute to an ideal peptide vector able to deliver cargoes across the bacterial outer membrane as the rising issue of antimicrobial resistance demands new strategies to be employed to combat this global public health threat.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RS Pharmacy and materia medica |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Peptide antibiotics, Microbial pesticides, Anti-infective agents, Peptides -- Physiological transport, Drug carriers (Pharmacy) | |||||||||||||||
Journal or Publication Title: | Antibiotics | |||||||||||||||
Publisher: | M.D.P.I.AG | |||||||||||||||
ISSN: | 2079-6382 | |||||||||||||||
Official Date: | 16 November 2022 | |||||||||||||||
Dates: |
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Volume: | 11 | |||||||||||||||
Number: | 11 | |||||||||||||||
Article Number: | 1636 | |||||||||||||||
DOI: | 10.3390/antibiotics11111636 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 8 February 2023 | |||||||||||||||
Date of first compliant Open Access: | 8 February 2023 | |||||||||||||||
RIOXX Funder/Project Grant: |
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