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Oscillatory Notch-pathway activity in a delay model of neuronal differentiation
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Momiji, Hiroshi and Monk, Nicholas A. M. (2009) Oscillatory Notch-pathway activity in a delay model of neuronal differentiation. Physical Review E (Statistical, Nonlinear, and Soft Matter Physics), Vol.80 (No.2 Part 1). Article no. 021930. doi:10.1103/PhysRevE.80.021930 ISSN 1539-3755.
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Official URL: http://dx.doi.org/10.1103/PhysRevE.80.021930
Abstract
Lateral inhibition resulting from a double-negative feedback loop underlies the assignment of different fates to cells in many developmental processes. Previous studies have shown that the presence of time delays in models of lateral inhibition can result in significant oscillatory transients before patterned steady states are reached. We study the impact of local feedback loops in a model of lateral inhibition based on the Notch signaling pathway, elucidating the roles of intracellular and intercellular delays in controlling the overall system behavior. The model exhibits both in-phase and out-of-phase oscillatory modes and oscillation death. Interactions between oscillatory modes can generate complex behaviors such as intermittent oscillations. Our results provide a framework for exploring the recent observation of transient Notch-pathway oscillations during fate assignment in vertebrate neurogenesis.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QC Physics | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Warwick HRI (2004-2010) |
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| Journal or Publication Title: | Physical Review E (Statistical, Nonlinear, and Soft Matter Physics) | ||||
| Publisher: | American Physical Society | ||||
| ISSN: | 1539-3755 | ||||
| Official Date: | August 2009 | ||||
| Dates: |
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| Volume: | Vol.80 | ||||
| Number: | No.2 Part 1 | ||||
| Number of Pages: | 13 | ||||
| Page Range: | Article no. 021930 | ||||
| DOI: | 10.1103/PhysRevE.80.021930 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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