Atterbury, Alison and Wall, M. (Mark). (2009) Adenosine signalling at immature parallel fibre-Purkinje cell synapses in rat cerebellum. Journal of Physiology, Vol.587 (No.18). pp. 4497-4508. ISSN 0022-3751

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Abstract

The purine adenosine is an extracellular signalling molecule involved in a large number of physiological and pathological conditions throughout the mammalian brain. However little is known about how adenosine release and its subsequent clearance change during brain development. We have combined electrophysiology and microelectrode biosensor measurements to investigate the properties of adenosine signalling at early stages of cerebellar development, when parallel fibre-Purkinje cell synapses have recently been formed (postnatal days 9-12). At this stage of development, we could detect little or no inhibitory A(1) receptor tone in basal conditions and during trains of stimuli. Addition of pharmacological agents, to inhibit adenosine clearance, had only minor effects on synaptic transmission suggesting that under basal conditions, the concentration of adenosine moving in and out of the extracellular space is small. Active adenosine release was stimulated with hypoxia and trains of electrical stimuli. Although hypoxia released significant concentrations of adenosine, the release was delayed and slow. No adenosine release could be detected following electrical stimulation in the molecular layer. In conclusion, at this stage of development, although adenosine receptors and the mechanisms of adenosine clearance are present there is very little adenosine release.

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Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Q Science > QP Physiology
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Journal or Publication Title:	Journal of Physiology
Publisher:	Wiley-Blackwell Publishing Ltd.
ISSN:	0022-3751
Date:	15 September 2009
Volume:	Vol.587
Number:	No.18
Number of Pages:	12
Page Range:	pp. 4497-4508
Identification Number:	10.1113/jphysiol.2009.176420
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Warwick Medical Research Fund
URI:	http://wrap.warwick.ac.uk/id/eprint/17322

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