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Abnormal expression of post-synaptic proteins in prefrontal cortex of patients with schizophrenia
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Matas, Emmanuel, John Francis William, Deakin and Toro, Carla T. (2021) Abnormal expression of post-synaptic proteins in prefrontal cortex of patients with schizophrenia. Neuroscience Letters, 745 . 135629. doi:10.1016/j.neulet.2021.135629 ISSN 0304-3940.
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Official URL: http://dx.doi.org/10.1016/j.neulet.2021.135629
Abstract
There is converging evidence of dendritic spine dysfunction in schizophrenia. In the present study we hypothesized that the expression of key proteins involved in dendritic spine development and stability may be affected in schizophrenia. Postmortem frontal cortex (BA6) from patients with schizophrenia, major depressive disorder, bipolar disorder and healthy controls was processed for glutamate post-synaptic fraction extraction and post-synaptic density purification. Protein expression of the post-synaptic fraction and the post-synaptic density was assessed using immunoprecipitation and Western blotting respectively. The expression of the N-methyl-d-aspartate glutamate receptor (NMDAR) subunit NR2A, post-synaptic density 95 (PSD-95), Ca2+/calmodulin-dependent protein kinase II subunits α and β (CaMKIIα and β) were significantly reduced in schizophrenia. A significant decrease in the expression of NR2A was also observed in patients with major depressive disorder relative to controls, but not in patients with bipolar disorder. These results add to existing evidence for disturbed post-synaptic glutamate function and synaptic plasticity in schizophrenia. There may also be subtle disturbances in the post-synaptic glutamatergic function in major depressive disorder.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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Journal or Publication Title: | Neuroscience Letters | ||||||||
Publisher: | Elsevier Ireland Ltd | ||||||||
ISSN: | 0304-3940 | ||||||||
Official Date: | 6 February 2021 | ||||||||
Dates: |
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Volume: | 745 | ||||||||
Article Number: | 135629 | ||||||||
DOI: | 10.1016/j.neulet.2021.135629 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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