The Library
The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England
Tools
Tools
Tools
Keeling, Matt J., Moore, Samuel, Penman, Bridget S. and Hill, Edward M. (2023) The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England. Nature Communications, 14 (1). 740. doi:10.1038/s41467-023-35943-0 ISSN 2041-1723.
|
PDF
WRAP-impacts-SARS-CoV-2-vaccine-dose-separation-targeting-COVID-19-epidemic-England-2023.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1401Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/s41467-023-35943-0
Abstract
In late 2020, the JCVI (the Joint Committee on Vaccination and Immunisation, which provides advice to the Department of Health and Social Care, England) made two important recommendations for the initial roll-out of the COVID-19 vaccine. The first was that vaccines should be targeted to older and vulnerable people, with the aim of maximally preventing disease rather than infection. The second was to increase the interval between first and second doses from 3 to 12 weeks. Here, we re-examine these recommendations through a mathematical model of SARS-CoV-2 infection in England. We show that targeting the most vulnerable had the biggest immediate impact (compared to targeting younger individuals who may be more responsible for transmission). The 12-week delay was also highly beneficial, estimated to have averted between 32-72 thousand hospital admissions and 4-9 thousand deaths over the first ten months of the campaign (December 2020–September 2021) depending on the assumed interaction between dose interval and efficacy.
| Item Type: | Journal Article | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | COVID-19 (Disease) -- Vaccination -- Great Britain, Vaccines -- Administration, Communicable diseases -- Prevention -- Great Britain, COVID-19 (Disease) -- Vaccination -- Great Britain -- Statistics, COVID-19 (Disease) --Great Britain -- Prevention | |||||||||||||||
| Journal or Publication Title: | Nature Communications | |||||||||||||||
| Publisher: | Nature Publishing Group | |||||||||||||||
| ISSN: | 2041-1723 | |||||||||||||||
| Official Date: | 10 February 2023 | |||||||||||||||
| Dates: |
|
|||||||||||||||
| Volume: | 14 | |||||||||||||||
| Number: | 1 | |||||||||||||||
| Article Number: | 740 | |||||||||||||||
| DOI: | 10.1038/s41467-023-35943-0 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 14 February 2023 | |||||||||||||||
| Date of first compliant Open Access: | 14 February 2023 | |||||||||||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
