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Artificial synapse : spatiotemporal heterogeneities in dopamine electrochemistry at a carbon fiber ultramicroelectrode
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Chen, Baoping, Perry, David, Teahan, James, McPherson, Ian J., Edmondson, James, Kang, Minkyung, Valavanis, Dimitrios, Frenguelli, Bruno G. and Unwin, Patrick R. (2021) Artificial synapse : spatiotemporal heterogeneities in dopamine electrochemistry at a carbon fiber ultramicroelectrode. ACS Measurement Science Au, 1 (1). pp. 6-10. doi:10.1021/acsmeasuresciau.1c00006 ISSN 2694-250X.
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Official URL: http://doi.org/10.1021/acsmeasuresciau.1c00006
Abstract
An artificial synapse is developed that mimics ultramicroelectrode (UME) amperometric detection of single cell exocytosis. It comprises the nanopipette of a scanning ion conductance microscope (SICM), which delivers rapid pulses of neurotransmitter (dopamine) locally and on demand at >1000 defined locations of a carbon fiber (CF) UME in each experiment. Analysis of the resulting UME current-space-time data reveals spatiotemporal heterogeneous electrode activity on the nanoscale and submillisecond time scale for dopamine electrooxidation at typical UME detection potentials. Through complementary surface charge mapping and finite element method (FEM) simulations, these previously unseen variations in electrochemical activity are related to heterogeneities in the surface chemistry of the CF UME.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
Journal or Publication Title: | ACS Measurement Science Au | ||||||
Publisher: | ACS | ||||||
ISSN: | 2694-250X | ||||||
Official Date: | 18 August 2021 | ||||||
Dates: |
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Volume: | 1 | ||||||
Number: | 1 | ||||||
Page Range: | pp. 6-10 | ||||||
DOI: | 10.1021/acsmeasuresciau.1c00006 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Copyright Holders: | Copyright © 2021 The Authors. Published by American Chemical Society | ||||||
Date of first compliant deposit: | 8 March 2023 | ||||||
Date of first compliant Open Access: | 8 March 2023 |
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