Differential modulation of hippocampal plasticity in a non-noxious conflict model for anxiety
Collins, Dawn R.. (2009) Differential modulation of hippocampal plasticity in a non-noxious conflict model for anxiety. Neuroscience, Vol.162 (No.4). pp. 863-869. ISSN 0306 4522Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.neuroscience.2009.06.0...
Modulation of synaptic strength may underlie stress-induced changes in cognitive ability. Long-term memory formation underpinning fear and anxiety behaviors, such as those seen in post-traumatic stress and phobic disorders, is thought to be dependent on amygdalo-hippocampal interactions. In most models, however, painful stimuli are used to induced stress and anxiety. Here, the effects of a novel conflict model, developed to generate a more naturalistic model of anxiety, utilizing two non-noxious stressors (predator (cat) odor and light), on hippocampus plasticity were determined. Exposure to the external stimuli elicited typical, stimulus-specific, anxiety-related behaviors. Dual presentation of the stressors evoked an increase in the variability of behaviors, suggesting that the animals were experiencing conflicting drives. Induction of long-term potentiation (LTP) within the CA1 region of the hippocampus was reduced following exposure to light stress, independent of presence, or absence, of odor. However, after a single presentation, LTP was reduced following either odor presentation or dual presentation of the stressors. Furthermore, LTP in ex vivo tissue obtained from conflict-exposed animals showed differential hemispheric responses, suggesting that long-term contextual-related components of anxiety behavior are dependent on modification of hippocampal circuitry. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Divisions:||Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Neuroscience|
|Official Date:||15 September 2009|
|Number of Pages:||7|
|Page Range:||pp. 863-869|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||UoW Research Development Fund, Wellcome Trust|
|Grant number:||RD06010, 073934|
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