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Differential modulation of hippocampal plasticity in a non-noxious conflict model for anxiety
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Collins, Dawn R. (2009) Differential modulation of hippocampal plasticity in a non-noxious conflict model for anxiety. Neuroscience, Vol.162 (No.4). pp. 863-869. doi:10.1016/j.neuroscience.2009.06.020 ISSN 0306 4522.
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Official URL: http://dx.doi.org/10.1016/j.neuroscience.2009.06.0...
Abstract
Modulation of synaptic strength may underlie stress-induced changes in cognitive ability. Long-term memory formation underpinning fear and anxiety behaviors, such as those seen in post-traumatic stress and phobic disorders, is thought to be dependent on amygdalo-hippocampal interactions. In most models, however, painful stimuli are used to induced stress and anxiety. Here, the effects of a novel conflict model, developed to generate a more naturalistic model of anxiety, utilizing two non-noxious stressors (predator (cat) odor and light), on hippocampus plasticity were determined. Exposure to the external stimuli elicited typical, stimulus-specific, anxiety-related behaviors. Dual presentation of the stressors evoked an increase in the variability of behaviors, suggesting that the animals were experiencing conflicting drives. Induction of long-term potentiation (LTP) within the CA1 region of the hippocampus was reduced following exposure to light stress, independent of presence, or absence, of odor. However, after a single presentation, LTP was reduced following either odor presentation or dual presentation of the stressors. Furthermore, LTP in ex vivo tissue obtained from conflict-exposed animals showed differential hemispheric responses, suggesting that long-term contextual-related components of anxiety behavior are dependent on modification of hippocampal circuitry. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Neuroscience | ||||
| Publisher: | Elsevier | ||||
| ISSN: | 0306 4522 | ||||
| Official Date: | 15 September 2009 | ||||
| Dates: |
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| Volume: | Vol.162 | ||||
| Number: | No.4 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 863-869 | ||||
| DOI: | 10.1016/j.neuroscience.2009.06.020 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | UoW Research Development Fund, Wellcome Trust | ||||
| Grant number: | RD06010, 073934 |
Data sourced from Thomson Reuters' Web of Knowledge
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