Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Hyperglycemic kidney damage in an animal model of prolonged critical illness

Tools
- Tools
+ Tools

Vanhorebeek, Ilse, Gunst, Jan, Ellger, Bjoern, Boussemaere, Magaly, Lerut, Evelyne, Debaveye, Yves, Rabbani, Naila, Thornalley, Paul J., Schetz, Miet and Van den Berghe, Greet (2009) Hyperglycemic kidney damage in an animal model of prolonged critical illness. In: 90th Annual Meeting of the Endocrine-Society, San Francisco, CA, June 15-18, 2008. Published in: Kidney International, Vol.76 (No.5). pp. 512-520. doi:10.1038/ki.2009.217 ISSN 0085-2538.

Research output not available from this repository.

Request-a-Copy directly from author or use local Library Get it For Me service.

Official URL: http://dx.doi.org/10.1038/ki.2009.217

Request Changes to record.

Abstract

Acute kidney injury frequently complicates critical illness and increases mortality; maintaining normoglycemia with insulin has been shown to reduce the incidence of intensive care unit (ICU)-acquired kidney injury. Here we tested the mechanisms by which this intervention might achieve its goal, using a rabbit model of burn-induced prolonged critical illness in which blood glucose and insulin were independently regulated at normal or elevated levels. Hyperglycemia caused elevated plasma creatinine and severe morphological kidney damage that correlated with elevated cortical glucose levels. Renal cortical perfusion and oxygen delivery were lower in hyperglycemic/hyperinsulinemic rabbits, compared to other groups, but this did not explain the elevated creatinine. Mitochondrial respiratory chain activities were severely reduced in the hyperglycemic groups (30-40% residual activity), and were inversely correlated with plasma creatinine and cortical glucose. These activities were much less affected by normoglycemia, and hyperinsulinemia was not directly protective. Mitochondrial damage, evident at day 3, preceded the structural injury evident at 7 days. Our study found that hyperglycemia evoked cellular glucose overload in the kidneys of critically ill rabbits, and this was associated with mitochondrial dysfunction and renal injury. Normoglycemia, independent of insulinemia, protected against this damage.

Item Type: Conference Item (Paper)
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Kidney International
Publisher: Nature Publishing Group
ISSN: 0085-2538
Official Date: September 2009
Dates:
DateEvent
September 2009Published
Volume: Vol.76
Number: No.5
Number of Pages: 9
Page Range: pp. 512-520
DOI: 10.1038/ki.2009.217
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Fund for Scientific Research (FWO, Research Council of the Katholieke Universiteit Leuven, KULeuven Research Council Postdoctoral Fellowships, FWO Research Assistant Fellowship, Innovative Medizinische Forschung, B Braun, Germany, British Heart Foundation Research Fellowship
Grant number: G.0533.06; GOA2007/14; EL 610304
Conference Paper Type: Paper
Title of Event: 90th Annual Meeting of the Endocrine-Society
Type of Event: Conference
Location of Event: San Francisco, CA
Date(s) of Event: June 15-18, 2008

Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us