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Sample preparation of atherosclerotic plaque for SAXS/WAXS experimentation
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Mackley, Rebecca, Huband, Steven and Schiller, Tara L. (2023) Sample preparation of atherosclerotic plaque for SAXS/WAXS experimentation. ACS Omega, 8 (15). pp. 13833-13839. doi:10.1021/acsomega.3c00060 ISSN 2470-1343.
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Official URL: https://doi.org/10.1021/acsomega.3c00060
Abstract
Atherosclerosis is often described as a single disease entity; however, the morphology of each plaque is unique to the individual. The field currently lacks a technique that can discriminate stable from unstable plaques, to identify those at risk of a thromboembolic event. Small- and wide-angle X-ray scattering (SAXS/WAXS) holds the potential to be able to identify key materials present in a plaque, such as cholesterol species, collagen, low-density lipoproteins (LDLs), and hydroxyapatite. Protocols have been established for the preparation of excised human atherosclerotic tissue that are investigated herein. This includes the fixing, sectioning, and substrate selection of the sample. Through several sample preparation methods, vast improvements have been made to sample-to-noise ratio and background subtraction.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QC Physics R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||||||
Library of Congress Subject Headings (LCSH): | Atherosclerosis, Atherosclerotic plaque, X-rays -- Scattering | ||||||||
Journal or Publication Title: | ACS Omega | ||||||||
Publisher: | American Chemical Society | ||||||||
ISSN: | 2470-1343 | ||||||||
Official Date: | 18 April 2023 | ||||||||
Dates: |
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Volume: | 8 | ||||||||
Number: | 15 | ||||||||
Page Range: | pp. 13833-13839 | ||||||||
DOI: | 10.1021/acsomega.3c00060 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 28 March 2023 | ||||||||
Date of first compliant Open Access: | 4 May 2023 | ||||||||
RIOXX Funder/Project Grant: |
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