Russo, Paola, Siani, Alfonso, Miller, Michelle A., Dr., Karanam, Sharada, Esposito, Teresa, Gianfrancesco, Fernando, Barba, Gianvincenzo, Lauria, Fabio, Strazzullo, Pasquale and Cappuccio, Francesco P.. (2008) Genetic variants of Y chromosome are associated with a protective lipid profile in black men. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.28 . pp. 1569-1574. ISSN 1079-5642

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Abstract

Objective— Gender and ethnicity modulate the phenotypic expression of cardiovascular risk factors. In particular, men are at higher risk of developing cardiovascular diseases compared to women, whereas black populations of African origin display reduced mortality from coronary heart disease (CHD) as compared to both whites and South Asians. Because the male-specific region (MSY) of the human Y chromosome is an obvious candidate for gender-related differences in the development of cardiovascular diseases, we aimed to identify genetic variants of MSY influencing cardiovascular risk profile in different ethnic groups. Methods and Results— We genotyped 4 polymorphisms of MSY (HindIII±, rs768983 of TBL1Y, rs3212292 of USP9Y, and rs9341273 of UTY genes) in 579 men of different ethnic groups (blacks, South Asians, and whites) from UK and in 301 whites in Italy. We found that the TBL1YA USP9YA haplotype, present only in blacks in whom it represents the most frequent allelic combinations (AA: n=125; all other combinations: n=45), was associated with lower levels of triglycerides (P=0.025) and higher levels of HDL-cholesterol (P=0.005) as compared to the other haplotypes. Conclusion— The TBL1YA USP9YA haplotype of the Y chromosome, present only in black people of African origin, attributes a favorable lipoprotein pattern, likely to contribute to their reduced susceptibility to coronary heart disease. The study evaluated the association of genetic variants of the male-specific region of the Y chromosome with cardiovascular risk factors in different ethnic groups. The most frequently observed haplotype in black people was associated with a favorable lipoprotein pattern, thus contributing to the lower rate of cardiovascular diseases in blacks.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Y chomosome, Cardiovascular system -- Diseases, Coronary heart disease, Ethnicity
Journal or Publication Title:	Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher:	American Heart Association, Inc.
ISSN:	1079-5642
Date:	29 May 2008
Volume:	Vol.28
Page Range:	pp. 1569-1574
Identification Number:	10.1161/ATVBAHA.108.168641
Status:	Peer Reviewed
Access rights to Published version:	Open Access
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URI:	http://wrap.warwick.ac.uk/id/eprint/175

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