The Library
The physiological role of the brain GLP-1 system in stress
Tools
Holt, Marie K., Trapp, Stefan and Wisden, William (2016) The physiological role of the brain GLP-1 system in stress. Cogent Biology, 2 (1). 1229086. doi:10.1080/23312025.2016.1229086 ISSN 2331-2025.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://doi.org/10.1080/23312025.2016.1229086
Abstract
Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated anorexia, including some which are not traditionally associated with appetite regulation. However, a change in food intake can be indicative of not only reduced energy demand, but also changes in the organism’s motivation to eat following stressful stimuli. In fact, acute stress is well-known to reduce food intake. Recently, more research has focused on the role of GLP-1 in stress and the central GLP-1 system has been found to be activated in response to stressful stimuli. The source of GLP-1 within the brain, the preproglucagon (PPG) neurons, are ideally situated in the brainstem to receive and relay signals of stress and our recent data on the projection pattern of the PPG neurons to the spinal cord suggest a potential strong link with the sympathetic nervous system. We review here the role of central GLP-1 in the regulation of stress responses and discuss the potential involvement of the endogenous source of GLP-1 within the brain, the PPG neurons.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Cogent Biology | ||||
Publisher: | Taylor & Francis | ||||
ISSN: | 2331-2025 | ||||
Official Date: | August 2016 | ||||
Dates: |
|
||||
Volume: | 2 | ||||
Number: | 1 | ||||
Article Number: | 1229086 | ||||
DOI: | 10.1080/23312025.2016.1229086 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |