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Outcome of T1N0M0 squamous cell carcinoma of the larynx treated with short-course radiotherapy to a total dose of 50 Gy in 16 fractions: the Birmingham experience
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Cheah, N. L. C., Lupton, S., Marshall, A. (Andrea), Hartley, A. and Glaholm, J. (2009) Outcome of T1N0M0 squamous cell carcinoma of the larynx treated with short-course radiotherapy to a total dose of 50 Gy in 16 fractions: the Birmingham experience. Clinical Oncology, Vol.21 (No.6). pp. 494-501. doi:10.1016/j.clon.2009.02.008 ISSN 0936-6555.
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Official URL: http://dx.doi.org/10.1016/j.clon.2009.02.008
Abstract
Aims: To review the results of hypofractionated radiotherapy in T1N0M0 squamous cell carcinoma of the larynx.
Materials and methods: A series of 100 patients treated with radiotherapy between 1993 and 2001 was reviewed. The median age was 67 years. The median follow-up was 7 years (range 3-14 years). Radiotherapy was delivered to a total dose of 50 Gy in 16 fractions treating daily, 5 days a week over 21 days.
Results: Locoregional control rates with radiotherapy alone were 92% at 2 years and 88% at 5 years. After salvage surgery, the ultimate locoregional control rate was 96%. The relapse-free survival rates at 2 and 5 years were 85 and 70%, respectively. The cause-specific survival rates at 2 and 5 years were 99 and 97%, respectively. Overall survival rates at 2 and 5 years were 91 and 76%, respectively. Second primary cancers occurred in 21% of patients, primarily in the lung.
Conclusions: Radiotherapy to a total dose of 50 Gy in 16 fractions for T1N0M0 squamous cell carcinoma of the larynx offers high locoregional control rates with voice preservation. These results from a hypofractionated radiotherapy schedule are comparable with other longer fractionation schedules and offer potential for optimising resource usage. Cheah, N. L. C. et at. (2009). Clinical Oncology 21, 494-501 (C) 2009 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Clinical Oncology | ||||
| Publisher: | Elsevier Science London | ||||
| ISSN: | 0936-6555 | ||||
| Official Date: | August 2009 | ||||
| Dates: |
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| Volume: | Vol.21 | ||||
| Number: | No.6 | ||||
| Number of Pages: | 8 | ||||
| Page Range: | pp. 494-501 | ||||
| DOI: | 10.1016/j.clon.2009.02.008 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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