The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor
UNSPECIFIED (1997) The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor. MOLECULAR & GENERAL GENETICS, 255 (2). pp. 226-236. ISSN 0026-8925Full text not available from this repository.
In the fission yeast Schizosaccharomyces pombe, cells of opposite mating type communicate via diffusible peptide pheromones prior to mating, We have cloned the S. pombe mam1 gene, which encodes a 1336-amino acid protein belonging to the ATP-binding cassette (ABC) superfamily. The mam1 gene is only expressed in M cells and the gene product is responsible for the secretion of the mating pheromone, M-factor, a nonapeptide that is S-farnesylated and carboxy-methylated on its C-terminal cysteine residue. The predicted Mam1 protein is highly homologous to mammalian multiple drug-resistance proteins and to the Saccharomyces cerevisiae STE6 gene product, which mediates export of a-factor mating pheromone. We show that STE6 call also mediate secretion of M-factor in S. pombe.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
Q Science > QH Natural history > QH426 Genetics
|Journal or Publication Title:||MOLECULAR & GENERAL GENETICS|
|Number of Pages:||11|
|Page Range:||pp. 226-236|
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