UNSPECIFIED (1997) The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor. MOLECULAR & GENERAL GENETICS, 255 (2). pp. 226-236. ISSN 0026-8925

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Abstract

In the fission yeast Schizosaccharomyces pombe, cells of opposite mating type communicate via diffusible peptide pheromones prior to mating, We have cloned the S. pombe mam1 gene, which encodes a 1336-amino acid protein belonging to the ATP-binding cassette (ABC) superfamily. The mam1 gene is only expressed in M cells and the gene product is responsible for the secretion of the mating pheromone, M-factor, a nonapeptide that is S-farnesylated and carboxy-methylated on its C-terminal cysteine residue. The predicted Mam1 protein is highly homologous to mammalian multiple drug-resistance proteins and to the Saccharomyces cerevisiae STE6 gene product, which mediates export of a-factor mating pheromone. We show that STE6 call also mediate secretion of M-factor in S. pombe.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history > QH426 Genetics
Journal or Publication Title:	MOLECULAR & GENERAL GENETICS
Publisher:	SPRINGER VERLAG
ISSN:	0026-8925
Date:	June 1997
Volume:	255
Number:	2
Number of Pages:	11
Page Range:	pp. 226-236
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/17586

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