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Illuminating the brain : revealing brain biochemistry with synchrotron x-ray spectromicroscopy
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Everett, James, Brooks, Jake, Lermyte, Frederik, Tjendana Tjhin, Vindy, Hands-Portman, Ian, Hill, Emily, Collingwood, Joanna F. and Telling, Neil D. (2023) Illuminating the brain : revealing brain biochemistry with synchrotron x-ray spectromicroscopy. Journal of Electron Spectroscopy and Related Phenomena, 266 . 147355. doi:10.1016/j.elspec.2023.147355 ISSN 0368-2048.
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Official URL: https://doi.org/10.1016/j.elspec.2023.147355
Abstract
The synchrotron x-ray spectromicroscopy technique Scanning Transmission X-ray Microscopy (STXM) offers a powerful means to examine the underlying biochemistry of biological systems, owing to its combined chemical sensitivity and nanoscale spatial resolution. Here we introduce and demonstrate methodology for the use of STXM to examine the biochemistry of the human brain. We then discuss how this approach can help us better understand the biochemical changes that occur during the development of degenerative brain disorders, potentially facilitating the development of new therapies for disease diagnosis and treatment.
Item Type: | Journal Article | |||||||||||||||||||||||||||||||||
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Subjects: | Q Science > QC Physics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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Library of Congress Subject Headings (LCSH): | X-ray microscopy, Scanning transmission electron microscopy, Brain -- Microscopy, Nervous system -- Degeneration | |||||||||||||||||||||||||||||||||
Journal or Publication Title: | Journal of Electron Spectroscopy and Related Phenomena | |||||||||||||||||||||||||||||||||
Publisher: | Elsevier Science BV | |||||||||||||||||||||||||||||||||
ISSN: | 0368-2048 | |||||||||||||||||||||||||||||||||
Official Date: | July 2023 | |||||||||||||||||||||||||||||||||
Dates: |
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Volume: | 266 | |||||||||||||||||||||||||||||||||
Article Number: | 147355 | |||||||||||||||||||||||||||||||||
DOI: | 10.1016/j.elspec.2023.147355 | |||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||||||||
Copyright Holders: | © 2023 The Author(s). Published by Elsevier B.V. | |||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 19 June 2023 | |||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 19 June 2023 | |||||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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