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Preserving cognitive function in patients with Alzheimer's disease : the Alzheimer's disease neuroprotection research initiative (ADNRI)
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(2023) Preserving cognitive function in patients with Alzheimer's disease : the Alzheimer's disease neuroprotection research initiative (ADNRI). Neuroprotection, 1 (2). pp. 84-98. doi:10.1002/nep3.23 ISSN 2770-730X.
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WRAP-preserving-cognitive-function-patients-Alzheimer's-disease-Alzheimer's-Disease-Neuroprotection-Research-Initiative-(ADNRI)-2023.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (618Kb) |
Official URL: https://doi.org/10.1002/nep3.23
Abstract
The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease (AD) and associated socioeconomic burdens. Abnormal metabolism of amyloid-β (Aβ) has been proposed as a significant pathomechanism in AD, supported by results of recent clinical trials using anti-Aβ antibodies. Nonetheless, the cognitive benefits of the current treatments are limited. The etiology of AD is multifactorial, encompassing Aβ and tau accumulation, neuroinflammation, demyelination, vascular dysfunction, and comorbidities, which collectively lead to widespread neurodegeneration in the brain and cognitive impairment. Hence, solely removing Aβ from the brain may be insufficient to combat neurodegeneration and preserve cognition. To attain effective treatment for AD, it is necessary to (1) conduct extensive research on various mechanisms that cause neurodegeneration, including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level; (2) identify neuroprotective intervention targets against different neurodegeneration mechanisms; and (3) discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD patients. The Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated, multidisciplinary efforts to develop systemic neuroprotective strategies to combat AD. The aim is to achieve mitigation of the full spectrum of pathological processes underlying AD, with the goal of halting or even reversing cognitive decline.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | |||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Alzheimer's disease, Alzheimer's disease -- Treatment, Alzheimer's disease -- Diagnosis, Nervous system -- Regeneration | |||||||||||||||||||||
Journal or Publication Title: | Neuroprotection | |||||||||||||||||||||
Publisher: | John Wiley & Sons, Inc. | |||||||||||||||||||||
ISSN: | 2770-730X | |||||||||||||||||||||
Official Date: | December 2023 | |||||||||||||||||||||
Dates: |
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Volume: | 1 | |||||||||||||||||||||
Number: | 2 | |||||||||||||||||||||
Page Range: | pp. 84-98 | |||||||||||||||||||||
DOI: | 10.1002/nep3.23 | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 25 August 2023 | |||||||||||||||||||||
Date of first compliant Open Access: | 11 October 2023 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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