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The synthesis of 3-phosphonocyclobutyl amino acid analogues of glutamic acid via diethyl 3-oxycyclobutylphosphonate, a versatile synthetic intermediate

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UNSPECIFIED (1997) The synthesis of 3-phosphonocyclobutyl amino acid analogues of glutamic acid via diethyl 3-oxycyclobutylphosphonate, a versatile synthetic intermediate. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (4). pp. 493-502. ISSN 0300-922X

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Abstract

A range of novel 3-phosphonocyclobutyl amino acids have been prepared via the versatile synthetic intermediate, diethyl 3-oxocyclobutylphosphonate, which is prepared in three steps from diethyl methylphosphonate. Elaboration of the 3-oxo functionality readily facilitates the synthesis of the 3-phosphonocyclobutyl amino acids.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Journal or Publication Title: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Publisher: ROYAL SOC CHEMISTRY
ISSN: 0300-922X
Date: 21 February 1997
Number: 4
Number of Pages: 10
Page Range: pp. 493-502
Publication Status: Published
URI: http://wrap.warwick.ac.uk/id/eprint/17936

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