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Protein target highlights in CASP15 : analysis of models by structure providers
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(2023) Protein target highlights in CASP15 : analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics, 91 (12). pp. 1571-1599. doi:10.1002/prot.26545 ISSN 0887-3585.
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Official URL: http://dx.doi.org/10.1002/prot.26545
Abstract
We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Journal or Publication Title: | Proteins: Structure, Function, and Bioinformatics | ||||||||
Publisher: | John Wiley & Sons Ltd. | ||||||||
ISSN: | 0887-3585 | ||||||||
Official Date: | December 2023 | ||||||||
Dates: |
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Volume: | 91 | ||||||||
Number: | 12 | ||||||||
Page Range: | pp. 1571-1599 | ||||||||
DOI: | 10.1002/prot.26545 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 6 February 2024 | ||||||||
Date of first compliant Open Access: | 6 February 2024 | ||||||||
Open Access Version: |
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