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A structural understanding of influenza virus genome replication
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Zhu, Zihan, Fodor, Ervin and Keown, Jeremy R. (2023) A structural understanding of influenza virus genome replication. Trends in Microbiology, 31 (3). pp. 308-319. doi:10.1016/j.tim.2022.09.015 ISSN 0966-842X.
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Official URL: http://doi.org/10.1016/j.tim.2022.09.015
Abstract
Influenza virus contains a single-stranded negative-sense RNA genome. Replication of the genome is carried out by the viral RNA-dependent RNA polymerase in the context of the viral ribonucleoprotein (RNP) complex, through a positive-sense complementary RNA intermediate. Genome replication is tightly controlled through interactions with accessory viral and host factors. Propelled by developments in recombinant protein expression, and technical improvements in X-ray crystallography and cryo-electron microscopy, snapshots of the replication process have been captured. Here, we review how recent structural data shed light on the molecular mechanisms of influenza virus genome replication, in particular, encapsidation of nascent RNA, de novo RNP assembly, and regulation of replication initiation through interactions with host and viral cues.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Journal or Publication Title: | Trends in Microbiology | ||||||||
Publisher: | Elsevier Ltd | ||||||||
ISSN: | 0966-842X | ||||||||
Official Date: | March 2023 | ||||||||
Dates: |
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Volume: | 31 | ||||||||
Number: | 3 | ||||||||
Page Range: | pp. 308-319 | ||||||||
DOI: | 10.1016/j.tim.2022.09.015 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) |
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