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Parallel evolution in the emergence of highly pathogenic avian influenza A viruses
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Escalera-Zamudio, Marina, Golden, Michael, Gutiérrez, Bernardo, Thézé, Julien, Keown, Jeremy R., Carrique, Loic, Bowden, Thomas A. and Pybus, Oliver G. (2020) Parallel evolution in the emergence of highly pathogenic avian influenza A viruses. Nature Communications, 11 (1). 5511. doi:10.1038/s41467-020-19364-x ISSN 2041-1723.
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Official URL: http://doi.org/10.1038/s41467-020-19364-x
Abstract
Parallel molecular evolution and adaptation are important phenomena commonly observed in viruses. Here, we exploit parallel molecular evolution to understand virulence evolution in avian influenza viruses (AIV). Highly-pathogenic AIVs evolve independently from low-pathogenic ancestors via acquisition of polybasic cleavage sites. Why some AIV lineages but not others evolve in this way is unknown. We hypothesise that the parallel emergence of highly-pathogenic AIV may be facilitated by permissive or compensatory mutations occurring across the viral genome. We combine phylogenetic, statistical and structural approaches to discover parallel mutations in AIV genomes associated with the highly-pathogenic phenotype. Parallel mutations were screened using a statistical test of mutation-phenotype association and further evaluated in the contexts of positive selection and protein structure. Our resulting mutational panel may help to reveal new links between virulence evolution and other traits, and raises the possibility of predicting aspects of AIV evolution.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Journal or Publication Title: | Nature Communications | ||||||
Publisher: | Nature Publishing Group | ||||||
ISSN: | 2041-1723 | ||||||
Official Date: | 2 November 2020 | ||||||
Dates: |
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Volume: | 11 | ||||||
Number: | 1 | ||||||
Article Number: | 5511 | ||||||
DOI: | 10.1038/s41467-020-19364-x | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Description: | A Publisher Correction to this article was published on 23 November 2020 |
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