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Global burden of peripheral artery disease and its risk factors, 1990–2019 : a systematic analysis for the Global Burden of Disease Study 2019
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(2023) Global burden of peripheral artery disease and its risk factors, 1990–2019 : a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Global Health, 11 (10). e1553-e1565. doi:10.1016/S2214-109X(23)00355-8 ISSN 2214-109X.
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Official URL: http://doi.org/10.1016/S2214-109X(23)00355-8
Abstract
peripheral artery disease were modelled using the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 database. Prevalence, disability-adjusted life years (DALYs), and mortality estimates of peripheral artery disease were extracted from GBD 2019. Total DALYs and age-standardised DALY rate of peripheral artery disease attributed to modifiable risk factors were also assessed.
Findings
In 2019, the number of people aged 40 years and older with peripheral artery disease was 113 million (95% uncertainty interval [UI] 99·2–128·4), with a global prevalence of 1·52% (95% UI 1·33–1·72), of which 42·6% was in countries with low to middle Socio-demographic Index (SDI). The global prevalence of peripheral artery disease was higher in older people, (14·91% [12·41–17·87] in those aged 80–84 years), and was generally higher in females than in males. Globally, the total number of DALYs attributable to modifiable risk factors in 2019 accounted for 69·4% (64·2–74·3) of total peripheral artery disease DALYs. The prevalence of peripheral artery disease was highest in countries with high SDI and lowest in countries with low SDI, whereas DALY and mortality rates showed U-shaped curves, with the highest burden in the high and low SDI quintiles.
Interpretation
The total number of people with peripheral artery disease has increased globally from 1990 to 2019. Despite the lower prevalence of peripheral artery disease in males and low-income countries, these groups showed similar DALY rates to females and higher-income countries, highlighting disproportionate burden in these groups. Modifiable risk factors were responsible for around 70% of the global peripheral artery disease burden. Public measures could mitigate the burden of peripheral artery disease by modifying risk factors.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
Library of Congress Subject Headings (LCSH): | Peripheral vascular diseases, Peripheral vascular diseases -- Risk factors, Arteries -- Diseases, Blood-vessels -- Diseases | ||||||||
Journal or Publication Title: | The Lancet Global Health | ||||||||
Publisher: | The Lancet Publishing Group | ||||||||
ISSN: | 2214-109X | ||||||||
Official Date: | October 2023 | ||||||||
Dates: |
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Volume: | 11 | ||||||||
Number: | 10 | ||||||||
Page Range: | e1553-e1565 | ||||||||
DOI: | 10.1016/S2214-109X(23)00355-8 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Copyright Holders: | © 2023 The Author(s). Published by Elsevier Ltd. | ||||||||
Date of first compliant deposit: | 12 October 2023 | ||||||||
Date of first compliant Open Access: | 13 October 2023 | ||||||||
RIOXX Funder/Project Grant: |
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