Nucleotide sequence of the gene encoding the viral polymerase of avian pneumovirus
UNSPECIFIED (1996) Nucleotide sequence of the gene encoding the viral polymerase of avian pneumovirus. JOURNAL OF GENERAL VIROLOGY, 77 (Part 12). pp. 3047-3051. ISSN 0022-1317Full text not available from this repository.
We report here the nucleotide sequence of the L gene of avian pneumovirus (APV). This is the second pneumovirus L gene and the second avian paramyxovirus L gene, following that of Newcastle disease virus, to be sequenced. The APV L gene is 6099 nucleotides long and encodes a single large ORF of 2004 amino acids. This makes the APV L protein the smallest to be described for any nonsegmented, negative-strand RNA virus. The protein contains six linear non-contiguous domains, a putative ATP-binding site and four polymerase motifs previously described for the L proteins of negative-strand RNA viruses. Phylogenetic analysis of domain III of 14 different L proteins suggests the pneumoviruses to be as distant in evolutionary terms from the other members of the Paramyxoviridae as are the Filoviridae.
|Item Type:||Journal Article|
|Subjects:||T Technology > TP Chemical technology
Q Science > QR Microbiology > QR355 Virology
|Journal or Publication Title:||JOURNAL OF GENERAL VIROLOGY|
|Publisher:||SOC GENERAL MICROBIOLOGY|
|Number of Pages:||5|
|Page Range:||pp. 3047-3051|
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