UNSPECIFIED (1996) Minimizing phylogenetic number to find good evolutionary trees. DISCRETE APPLIED MATHEMATICS, 71 (1-3). pp. 111-136.

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Abstract

Inferring phylogenetic trees is a fundamental problem in computational biology. We present a new objective criterion, the phylogenetic number, for evaluating evolutionary trees for species defined by biomolecular sequences or other qualitative characters. The phylogenetic number of a tree T is the maximum number of times that any given character state arises in T. By contrast, the classical parsimony criterion measures the total number of times that different character states arise in T. We consider the following related problems: finding the tree with minimum phylogenetic number, and computing the phylogenetic number of a given topology in which only the leaves are labeled by species. When the number of states is bounded (as is the case for biomolecular sequence characters), we can solve the second problem in polynomial time. Given the topology for an evolutionary tree, we can also compute a phylogeny with phylogenetic number 2 (when one exists) for an arbitrary number of states. This algorithm can be used to further distinguish trees that are equal under parsimony. We also consider st number of other related problems.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics
Journal or Publication Title:	DISCRETE APPLIED MATHEMATICS
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0166-218X
Official Date:	5 December 1996
Dates:	Date Event 5 December 1996 UNSPECIFIED
Volume:	71
Number:	1-3
Number of Pages:	26
Page Range:	pp. 111-136
Publication Status:	Published

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