UNSPECIFIED (1996) Dynamic modeling of epidemiologic patterns of schistosomiasis morbidity. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 55 (5 Suppl. S). pp. 149-158. ISSN 0002-9637

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Abstract

This paper uses preliminary mathematical models to examine how the dynamic relationship between schistosomiasis infection and disease is altered by chemotherapy. Two types of morbidity are examined: an acute form that is proportional to current infection intensity and that resolves after treatment, and a chronic form that represents accumulated experience of infection and that does not resolve after treatment, or resolves according to some delay function. The analyses indicate that nonlinearities in the age and frequency distributions of infection intensity have a marked impact on the patterns of morbidity. They also suggest that treatment close to the age of maximum infection intensity (i.e., children of schoolage) is most effective in controlling morbidity in the community as a whole. These models are preliminary, and their further development to include more realistic assumptions in relation to field data is discussed.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine
Journal or Publication Title:	AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Publisher:	AMER SOC TROP MED & HYGIENE
ISSN:	0002-9637
Date:	November 1996
Volume:	55
Number:	5 Suppl. S
Number of Pages:	10
Page Range:	pp. 149-158
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/18199

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