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Design, synthesis and applications of a ketone reduction catalyst containing a phosphinamide combined with a dioxaborolidine unit.
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UNSPECIFIED (1996) Design, synthesis and applications of a ketone reduction catalyst containing a phosphinamide combined with a dioxaborolidine unit. TETRAHEDRON-ASYMMETRY, 7 (11). pp. 3071-3074. ISSN 0957-4166
Full text not available from this repository.Abstract
We have designed and prepared a catalyst for the asymmetric reduction of ketones which combines a phosphinamide and a boron-containing heterocyclic ring. The former group acts to direct and activated the borane, whilst the latter provides a well defined position for location of the ketone. The resulting reduction therefore takes place in a well-defined stereochemical environment. Enantiomeric excesses of up to 59%, in a predictable absolute sense, were achieved. Evidence that O- co-ordination of borane is important in the reduction mechanism is also presented Copyright (C) 1996 Elsevier Science Ltd
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Journal or Publication Title: | TETRAHEDRON-ASYMMETRY |
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
| ISSN: | 0957-4166 |
| Date: | November 1996 |
| Volume: | 7 |
| Number: | 11 |
| Number of Pages: | 4 |
| Page Range: | pp. 3071-3074 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/18212 |
Data sourced from Thomson Reuters' Web of Knowledge
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