Antimicrobial activity of an iron triple helicate
Richards, Adair D., Rodger, Alison, Hannon, Michael J. and Bolhuis, Albert. (2009) Antimicrobial activity of an iron triple helicate. International Journal of Antimicrobial Agents, Vol.33 (No.5). pp. 469-472. ISSN 0924-8579
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Official URL: http://dx.doi.org/10.1016/j.ijantimicag.2008.10.03...
The prevalence of antibiotic resistance has resulted in the need for new approaches to be developed to combat previously easily treatable infections. Here we investigated the potential of the synthetic metallomolecules [Fe2L3]4+ and [Cu2(L’)2]2+ as antibacterial agents. Both molecules have been shown to bind DNA; [Fe2L3]4+ binds in the major groove and causes DNA coiling, whilst [Cu2(L’)2]2+ can act as an artificial nuclease. The work described here shows that only [Fe2L3]4+ is bactericidal for Bacillus subtilis and Escherichia coli. We demonstrate that [Fe2L3]4+ binds bacterial DNA in vivo and, strikingly, that it kills B. subtilis cells very rapidly.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Divisions:||Faculty of Science > Chemistry|
|Library of Congress Subject Headings (LCSH):||Organometallic compounds, Anti-infective agents, DNA-binding proteins, Antibacterial agents, Drug resistance in microorganisms|
|Journal or Publication Title:||International Journal of Antimicrobial Agents|
|Page Range:||pp. 469-472|
|Access rights to Published version:||Open Access|
|Funder:||Royal Society (Great Britain), Engineering and Physical Sciences Research Council (EPSRC)|
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