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Antimicrobial activity of an iron triple helicate

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Richards, Adair D., Rodger, Alison, Hannon, Michael J. and Bolhuis, Albert. (2009) Antimicrobial activity of an iron triple helicate. International Journal of Antimicrobial Agents, Vol.33 (No.5). pp. 469-472. ISSN 0924-8579

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Official URL: http://dx.doi.org/10.1016/j.ijantimicag.2008.10.03...

Abstract

The prevalence of antibiotic resistance has resulted in the need for new approaches to be developed to combat previously easily treatable infections. Here we investigated the potential of the synthetic metallomolecules [Fe2L3]4+ and [Cu2(L’)2]2+ as antibacterial agents. Both molecules have been shown to bind DNA; [Fe2L3]4+ binds in the major groove and causes DNA coiling, whilst [Cu2(L’)2]2+ can act as an artificial nuclease. The work described here shows that only [Fe2L3]4+ is bactericidal for Bacillus subtilis and Escherichia coli. We demonstrate that [Fe2L3]4+ binds bacterial DNA in vivo and, strikingly, that it kills B. subtilis cells very rapidly.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Organometallic compounds, Anti-infective agents, DNA-binding proteins, Antibacterial agents, Drug resistance in microorganisms
Journal or Publication Title:	International Journal of Antimicrobial Agents
Publisher:	Elsevier BV
ISSN:	0924-8579
Date:	May 2009
Volume:	Vol.33
Number:	No.5
Page Range:	pp. 469-472
Identification Number:	10.1016/j.ijantimicag.2008.10.031
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Royal Society (Great Britain), Engineering and Physical Sciences Research Council (EPSRC)
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URI:	http://wrap.warwick.ac.uk/id/eprint/1831