UNSPECIFIED. (1996) Epidemiological Patterns of hepatitis B virus (HBV) in highly endemic areas. EPIDEMIOLOGY AND INFECTION, 117 (2). pp. 313-325. ISSN 0950-2688

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Abstract

This paper uses meta-analysis of published data and a deterministic mathematical model of hepatitis B virus (HBV) transmission to describe the patterns of HBV infection in high endemicity areas. We describe the association between the prevalence of carriers and a simple measure of the rate of infection, the age at which half the population have been infected (A(50)), and assess the contribution of horizontal and perinatal transmission to this association. We found that the two main hyper-endemic areas of sub-Saharan Africa and east Asia have similar prevalences of carriers and values of A(50), and that there is a negative nonlinear relationship between A(50) and the prevalence of carriers in high endemicity areas (Spearman's Rank, P = 0.0086). We quantified the risk of perinatal transmission and the age-dependent rate of infection to allow a comparison between the main hyper-endemic areas. East Asia was found to have higher prevalences of HBeAg positive mothers and a greater risk of perinatal transmission from HBeAg positive mothers than sub-Saharan Africa, though the differences were not statistically significant. However, the two areas have similar magnitudes and age-dependent rates of horizontal transmission. Results of a simple compartmental model suggest that similar rates of horizontal transmission are sufficient to generate the similar patterns between A(50) and the prevalences of carriers. Interrupting horizontal transmission by mass immunization is expected to have a significant, nonlinear impact on the rate of acquisition of new carriers.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	EPIDEMIOLOGY AND INFECTION
Publisher:	CAMBRIDGE UNIV PRESS
ISSN:	0950-2688
Date:	October 1996
Volume:	117
Number:	2
Number of Pages:	13
Page Range:	pp. 313-325
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/18316

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