Effects of retinoic acid on Xenopus embryos
UNSPECIFIED (1996) Effects of retinoic acid on Xenopus embryos. In: Conference on Extracellular Regulators of Differentiation and Development, 1995, UNIV LEICESTER, LEICESTER, ENGLAND.Full text not available from this repository.
Retinoic acid (RA) has powerful dose-dependent dysmorphogenic effects on Xenopus embryos. The defects produced are dependent upon the stage and duration of treatment. Characteristic dysmorphogenic effects occur in the visceral (branchial) arch region and the tail. These regions correspond to the domains of expression of the retinoid receptors RAR gamma and RXR beta. By expressing domain-swapped and dominant negative derivatives of RAR gamma in embryos, we have shown that the effects of RA are mediated transcriptionally. Furthermore, the expression of dominant negative receptors in the absence of exogenous ligand has no apparent harmful effect upon early development. Finally, we have identified a novel MAP kinase phosphatase whose expression pattern is localized to regions similar to RAR gamma, and which is upregulated by RA.
|Item Type:||Conference Item (UNSPECIFIED)|
|Subjects:||Q Science > QD Chemistry|
|Series Name:||BIOCHEMICAL SOCIETY SYMPOSIUM|
|Journal or Publication Title:||EXTRACELLULAR REGULATORS OF DIFFERENTIATION AND DEVELOPMENT|
|Publisher:||PORTLAND PRESS LTD|
|Editor:||Chapman, K and Jackson, SP and Wilkinson, DG and Lunt, GG|
|Number of Pages:||18|
|Page Range:||pp. 157-174|
|Title of Event:||Conference on Extracellular Regulators of Differentiation and Development|
|Location of Event:||UNIV LEICESTER, LEICESTER, ENGLAND|
|Date(s) of Event:||1995|
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