UNSPECIFIED (1996) Plasma membrane perturbation induced by organotins on erythrocytes from Salmo irideus trout. APPLIED ORGANOMETALLIC CHEMISTRY, 10 (6). pp. 451-457. ISSN 0268-2605

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Abstract

Tributyltin chloride and its degradation products monobutyltin and dibutyltin act as water pollutants, owing to the use of tributyltin chloride as a biocide in marine paint formulations. These compounds are lipid-soluble and undergo bioaccumulation and bioconcentration. Salmo irideus trout erythrocytes were studied to evaluate the possible effects of these compounds on freshwater fish, which could be exposed to long-term effects due to bioaccumulation or organotins. Data showed that tributyltin increases the haemolysis rate, starting at 10 mu M, while dibutyltin has a scant protective effect at each concentration tested. Similar studies were performed in the presence of carbon monoxide (CO), which is protecting against membrane oxidation. In these conditions all the organotins tested induced an increase in the haemolysis rate. These results suggest that the consequence of auto-oxidation of Hb could condition the effects of some organotin compounds. Steady-state fluorescence of probes embedded in the lipidic part of the membrane was used to evaluate the modifications induced by organotins to the physico-chemical state of phospholipids.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Journal or Publication Title:	APPLIED ORGANOMETALLIC CHEMISTRY
Publisher:	JOHN WILEY & SONS LTD
ISSN:	0268-2605
Date:	August 1996
Volume:	10
Number:	6
Number of Pages:	7
Page Range:	pp. 451-457
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/18508

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