UNSPECIFIED (1996) Flash chiral chromatography with cellulose tris(3,5-dimethylphenylcarbamate)-coated phases Improved resolution of basic analytes. In: 19th International Symposium on Column Liquid Chromatography, INNSBRUCK, AUSTRIA, MAY 28-JUN 02, 1995. Published in: JOURNAL OF CHROMATOGRAPHY A, 728 (1-2). pp. 195-199.

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Abstract

The preparative resolution of some chiral basic analytes on a flash chiral chromatography column packed with a cellulose carbamate-coated phase is described. Compared with separations obtained, on a column packed with 20% (w/w) cellulose tris(3,5-dimethylphenylcarbamate) coated onto underivatised flash silica (40-63 mu m Davisil, 150 Angstrom), a substantial improvement was observed when the support medium was changed to octadecylated silica (37-55 mu m Bondapak ODS, 300 Angstrom). The ODS phase is extremely effective for the preparative separation of basic analytes such as beta-blockers and the optimum conditions can be readily established by the use of a related high-pressure liquid chromatography column containing the chiral carbamate coated onto Nucleosil-ODS (5 mu m, 300 Angstrom).

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	Q Science > QD Chemistry
Journal or Publication Title:	JOURNAL OF CHROMATOGRAPHY A
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0021-9673
Date:	29 March 1996
Volume:	728
Number:	1-2
Number of Pages:	5
Page Range:	pp. 195-199
Publication Status:	Published
Title of Event:	19th International Symposium on Column Liquid Chromatography
Location of Event:	INNSBRUCK, AUSTRIA
Date(s) of Event:	MAY 28-JUN 02, 1995
URI:	http://wrap.warwick.ac.uk/id/eprint/18868

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