UNSPECIFIED (1996) The human homolog T of the mouse T(Brachyury) gene: Gene structure, cDNA sequence, and assignment to chromosome 6q27. [Journal Item]

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Abstract

We have cloned the human gene encoding the transcription factor T. T protein is vital for the formation of posterior mesoderm and axial development in all vertebrates. Brachyury mutant mice, which lack T protein, die in utero With abnormal notochord, posterior somites, and allantois. We have identified human T genomic clones and derived the mRNA sequence and gene structure. There is 91% amino acid identity between human and mouse T proteins overall and complete identity across 77 amino acids of the T-box motif within the DNA-binding domain. Human T expression is very similar to that found for T in other vertebrate species and is confined to cells derived From the notochord. The human T gene maps to chromosome 6q27 and is only the second human member of the T-box gene Family to be described.

Item Type:	Journal Item
Subjects:	Q Science > QD Chemistry T Technology > TP Chemical technology Q Science > QH Natural history > QH426 Genetics
Journal or Publication Title:	GENOME RESEARCH
Publisher:	COLD SPRING HARBOR LAB PRESS
ISSN:	1054-9803
Date:	March 1996
Volume:	6
Number:	3
Number of Pages:	8
Page Range:	pp. 226-233
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/18941

Data sourced from Thomson Reuters' Web of Knowledge

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