The human homolog T of the mouse T(Brachyury) gene: Gene structure, cDNA sequence, and assignment to chromosome 6q27
UNSPECIFIED (1996) The human homolog T of the mouse T(Brachyury) gene: Gene structure, cDNA sequence, and assignment to chromosome 6q27. GENOME RESEARCH, 6 (3). pp. 226-233. ISSN 1054-9803Full text not available from this repository.
We have cloned the human gene encoding the transcription factor T. T protein is vital for the formation of posterior mesoderm and axial development in all vertebrates. Brachyury mutant mice, which lack T protein, die in utero With abnormal notochord, posterior somites, and allantois. We have identified human T genomic clones and derived the mRNA sequence and gene structure. There is 91% amino acid identity between human and mouse T proteins overall and complete identity across 77 amino acids of the T-box motif within the DNA-binding domain. Human T expression is very similar to that found for T in other vertebrate species and is confined to cells derived From the notochord. The human T gene maps to chromosome 6q27 and is only the second human member of the T-box gene Family to be described.
|Item Type:||Journal Item|
|Subjects:||Q Science > QD Chemistry
T Technology > TP Chemical technology
Q Science > QH Natural history > QH426 Genetics
|Journal or Publication Title:||GENOME RESEARCH|
|Publisher:||COLD SPRING HARBOR LAB PRESS|
|Official Date:||March 1996|
|Number of Pages:||8|
|Page Range:||pp. 226-233|
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