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Structural identifiability of models characterizing saturable binding: Comparison of pseudo-steady-state and non-pseudo-steady-state model formulations
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UNSPECIFIED (1996) Structural identifiability of models characterizing saturable binding: Comparison of pseudo-steady-state and non-pseudo-steady-state model formulations. MATHEMATICAL BIOSCIENCES, 133 (1). pp. 1-20. ISSN 0025-5564.
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Abstract
A two-state variable model in which saturable binding takes place is studied. Two mathematical representations of the same model are considered, one a standard chemical kinetics type of polynomial system, the other a reduced model formed from the original system via a pseudo-steady-state approximation. For a particular experiment the structural identifiability of the set of unknown parameters of each model is examined using the similarity transformation approach. The analysis shows that when the pseudo-steady-state approximation is-made a certain degree of structural identifiability is lost in the sense that fewer individual parameters can be uniquely identified. `
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
Journal or Publication Title: | MATHEMATICAL BIOSCIENCES | ||||
Publisher: | ELSEVIER SCIENCE INC | ||||
ISSN: | 0025-5564 | ||||
Official Date: | 1 April 1996 | ||||
Dates: |
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Volume: | 133 | ||||
Number: | 1 | ||||
Number of Pages: | 20 | ||||
Page Range: | pp. 1-20 | ||||
Publication Status: | Published |
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