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Structural identifiability of models characterizing saturable binding: Comparison of pseudo-steady-state and non-pseudo-steady-state model formulations
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UNSPECIFIED (1996) Structural identifiability of models characterizing saturable binding: Comparison of pseudo-steady-state and non-pseudo-steady-state model formulations. MATHEMATICAL BIOSCIENCES, 133 (1). pp. 1-20. ISSN 0025-5564
Full text not available from this repository.Abstract
A two-state variable model in which saturable binding takes place is studied. Two mathematical representations of the same model are considered, one a standard chemical kinetics type of polynomial system, the other a reduced model formed from the original system via a pseudo-steady-state approximation. For a particular experiment the structural identifiability of the set of unknown parameters of each model is examined using the similarity transformation approach. The analysis shows that when the pseudo-steady-state approximation is-made a certain degree of structural identifiability is lost in the sense that fewer individual parameters can be uniquely identified. `
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Journal or Publication Title: | MATHEMATICAL BIOSCIENCES |
| Publisher: | ELSEVIER SCIENCE INC |
| ISSN: | 0025-5564 |
| Date: | 1 April 1996 |
| Volume: | 133 |
| Number: | 1 |
| Number of Pages: | 20 |
| Page Range: | pp. 1-20 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/18948 |
Data sourced from Thomson Reuters' Web of Knowledge
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