The Library
Variation in the fusion glycoprotein gene of human respiratory syncytial virus subgroup A
Tools
Tools
Tools
UNSPECIFIED (1995) Variation in the fusion glycoprotein gene of human respiratory syncytial virus subgroup A. VIRUS GENES, 11 (1). pp. 37-45.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Abstract
Six different genotypes (designated lineages SHL1-6) of human respiratory syncytial (RS) virus have been defined by partial nucleotide sequence analysis of the variable SH and the hypervariable G membrane protein genes, and by restriction fragment analysis of the conserved N protein gene of viruses isolated in south Birmingham. Viruses of very similar genotype appear to be present worldwide at the present time. We have determined the nucleotide sequences of the fusion protein genes of five viruses isolated in south Birmingham in the same year, but belonging to different lineages, and have compared them with the sequences of four subgroup A viruses isolated at earlier times from diverse localities. The sequence diversity of the F genes of these five viruses, as measured by nucleotide (94.5-98.5%) and inferred amino acid (97.0-99.3%) identities, is comparable with that of the nine subgroup A viruses considered as a whole. No sequence changes occur in any of the sites of known epitopes. Comparison of the nine subgroup A sequences with the published sequences of a subgroup B strain and three bovine RS viruses confirms that the F protein sequences are most divergent in the F-2 region.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology > QR355 Virology |
||||
| Journal or Publication Title: | VIRUS GENES | ||||
| Publisher: | KLUWER ACADEMIC PUBL | ||||
| ISSN: | 0920-8569 | ||||
| Official Date: | 1995 | ||||
| Dates: |
|
||||
| Volume: | 11 | ||||
| Number: | 1 | ||||
| Number of Pages: | 9 | ||||
| Page Range: | pp. 37-45 | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
