UNSPECIFIED (1995) Variation in the fusion glycoprotein gene of human respiratory syncytial virus subgroup A. VIRUS GENES, 11 (1). pp. 37-45. ISSN 0920-8569

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Abstract

Six different genotypes (designated lineages SHL1-6) of human respiratory syncytial (RS) virus have been defined by partial nucleotide sequence analysis of the variable SH and the hypervariable G membrane protein genes, and by restriction fragment analysis of the conserved N protein gene of viruses isolated in south Birmingham. Viruses of very similar genotype appear to be present worldwide at the present time. We have determined the nucleotide sequences of the fusion protein genes of five viruses isolated in south Birmingham in the same year, but belonging to different lineages, and have compared them with the sequences of four subgroup A viruses isolated at earlier times from diverse localities. The sequence diversity of the F genes of these five viruses, as measured by nucleotide (94.5-98.5%) and inferred amino acid (97.0-99.3%) identities, is comparable with that of the nine subgroup A viruses considered as a whole. No sequence changes occur in any of the sites of known epitopes. Comparison of the nine subgroup A sequences with the published sequences of a subgroup B strain and three bovine RS viruses confirms that the F protein sequences are most divergent in the F-2 region.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	VIRUS GENES
Publisher:	KLUWER ACADEMIC PUBL
ISSN:	0920-8569
Date:	1995
Volume:	11
Number:	1
Number of Pages:	9
Page Range:	pp. 37-45
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/19137

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