YEAST CATALYZED REDUCTION OF BETA-KETO-ESTERS .2. OPTIMIZATION OF THE STEREOSPECIFIC REDUCTION BY ZYGOSACCHAROMYCES-ROUXII
UNSPECIFIED. (1995) YEAST CATALYZED REDUCTION OF BETA-KETO-ESTERS .2. OPTIMIZATION OF THE STEREOSPECIFIC REDUCTION BY ZYGOSACCHAROMYCES-ROUXII. BIOCATALYSIS AND BIOTRANSFORMATION, 12 (3). pp. 179-191. ISSN 1024-2422Full text not available from this repository.
Zygosaccharomyces rouxii catalysed the reduction of ethyl 4-chloroacetoacetate (ethyl 4-chloro-3-oxobutanoate) to the corresponding (S)-hydroxy ester (ethyl (S)-4-chloro-3-hydroxybutanoate) in high enantiomeric excess. The productivity of non-immobilised cells was compared to cells immobilised on a range of organic and inorganic supports. Cells immobilised in calcium alginate displayed a catalytic activity significantly higher than that of non-immobilised cells. A time dependent fall in the enantiomeric purity of the product was observed with the use of this matrix. This phenomenon was not seen in the reduction catalysed by non-immobilised cells.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
T Technology > TP Chemical technology
|Journal or Publication Title:||BIOCATALYSIS AND BIOTRANSFORMATION|
|Publisher:||HARWOOD ACAD PUBL GMBH|
|Number of Pages:||13|
|Page Range:||pp. 179-191|
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