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THE CONTRACEPTIVE EFFECTS OF ETOPRINE ON MALE-MICE AND RATS
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UNSPECIFIED (1995) THE CONTRACEPTIVE EFFECTS OF ETOPRINE ON MALE-MICE AND RATS. JOURNAL OF ANDROLOGY, 16 (2). pp. 169-174. ISSN 0196-3635.
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Abstract
We had previously found that 2,4-diaminopyrimidines affected spermatogenesis, possibly through the inhibition of testicular dihydrofolate reductase (DHFR). The current study examined the effects of etoprine, a highly lipophilic 2,4-diaminopyrimidine that is also a potent DHFR inhibitor, on the fertility of male mice at various dosages (0.1-50 mg/kg/day) for 55 days and male rats at 5 mg/kg/ day for 65 days. Two other substituted diaminopyrimidines were tested at dosages of 50 mg/kg/day for 55 days. Results of breeding trials along with assessment of various parameters indicative of male fertility were noted. We found that of the compounds tested, etoprine is a potent antifertility agent that causes complete infertility at doses of greater than or equal to 5 mg/kg/day in mice with a threshold of effectiveness occurring between 1 and 5 mg/kg/day. The antifertility action of etoprine may be related to its capacity to inhibit testicular DHFR and its high degree of lipophilicity.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine | ||||
Journal or Publication Title: | JOURNAL OF ANDROLOGY | ||||
Publisher: | AMER SOC ANDROLOGY, INC | ||||
ISSN: | 0196-3635 | ||||
Official Date: | March 1995 | ||||
Dates: |
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Volume: | 16 | ||||
Number: | 2 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 169-174 | ||||
Publication Status: | Published |
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