THE CONTRACEPTIVE EFFECTS OF ETOPRINE ON MALE-MICE AND RATS
UNSPECIFIED. (1995) THE CONTRACEPTIVE EFFECTS OF ETOPRINE ON MALE-MICE AND RATS. JOURNAL OF ANDROLOGY, 16 (2). pp. 169-174. ISSN 0196-3635Full text not available from this repository.
We had previously found that 2,4-diaminopyrimidines affected spermatogenesis, possibly through the inhibition of testicular dihydrofolate reductase (DHFR). The current study examined the effects of etoprine, a highly lipophilic 2,4-diaminopyrimidine that is also a potent DHFR inhibitor, on the fertility of male mice at various dosages (0.1-50 mg/kg/day) for 55 days and male rats at 5 mg/kg/ day for 65 days. Two other substituted diaminopyrimidines were tested at dosages of 50 mg/kg/day for 55 days. Results of breeding trials along with assessment of various parameters indicative of male fertility were noted. We found that of the compounds tested, etoprine is a potent antifertility agent that causes complete infertility at doses of greater than or equal to 5 mg/kg/day in mice with a threshold of effectiveness occurring between 1 and 5 mg/kg/day. The antifertility action of etoprine may be related to its capacity to inhibit testicular DHFR and its high degree of lipophilicity.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine|
|Journal or Publication Title:||JOURNAL OF ANDROLOGY|
|Publisher:||AMER SOC ANDROLOGY, INC|
|Number of Pages:||6|
|Page Range:||pp. 169-174|
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