UNSPECIFIED. (1995) EVOLUTION OF SUBGROUP-A RESPIRATORY SYNCYTIAL VIRUS - EVIDENCE FOR PROGRESSIVE ACCUMULATION OF AMINO-ACID CHANGES IN THE ATTACHMENT PROTEIN. JOURNAL OF VIROLOGY, 69 (5). pp. 2918-2925. ISSN 0022-538X

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Abstract

The variability of the attachment (G) proteins of 48 subgroup A isolates of respiratory syncytial virus (RSV) isolated over 38 years has been examined. Nucleotide sequences of two variable regions of the G protein genes were determined following amplification by PCR. The isolates showed temporal rather than geographical clustering, and there was evidence for progressive accumulation of amino acid changes at an average rate of approximately 0.25% per year estimated over the entire protein. The cocirculation of lineages of RSV at present appears to be the result of a process of evolution and survival of particular genotypes and the extinction of others. Analysis of reactivity of the isolates with monoclonal antibodies showed that their antigenic profiles closely paralleled their relatedness by nucleotide sequence, suggesting that antigenic drift due to immune selection may be occurring.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	JOURNAL OF VIROLOGY
Publisher:	AMER SOC MICROBIOLOGY
ISSN:	0022-538X
Date:	May 1995
Volume:	69
Number:	5
Number of Pages:	8
Page Range:	pp. 2918-2925
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/19883

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